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EC number: 241-230-3 | CAS number: 17185-29-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a guideline study, to GLP, carbonylhydridotris(triphenylphosphane)-rhodium(I) was not irritating to the skin of rabbits following a 4-hr occlusive application (Zechel, 1990).
In a guideline study, to GLP, carbonylhydridotris(triphenylphosphane)-rhodium(I) was not irritating to rabbit eyes following instillation of 0.038 or 0.032 g (volume 0.1 mL) of the test material to the conjunctival sac of 3 animals (Berthold, 1991b).
No relevant respiratory tract irritation data were identified.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 404)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The humidity went down to 30% “for a short period; this deviation was without any influence on the results of the study”. Also, the patch was occluded, rather than semi-occluded.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: White Russian (Albino)
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: ASTA Pharma AG
- Age at study initiation: 7-12 months
- Weight at study initiation: 2.59-2.77 kg
- Housing: Stainless steel cages with grating floor, size 48.5 cm(l) x 40 cm (b) x 36.5 cm (h); 1/cage
- Diet (e.g. ad libitum): Standard diet, Ssniff K, special diet for rabbits; ~120 g/day per animal
- Water (e.g. ad libitum): municipal drinking water, automatic drinking water system with drinking nipples; ad libitum
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22.5
- Humidity (%): 30-70
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: not stated- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: control area on opposite flank of each treated animal
- Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): not applicable, moistened
VEHICLE
- Amount(s) applied (volume or weight with unit): not applicable, enough to moisten test material
- Concentration (if solution): not applicable, moistened
- Lot/batch no. (if required): not applicable
- Purity: demineralised water- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after patch removal (all 3 animals), then daily to day 6 (1 animal)
- Number of animals:
- 3
- Details on study design:
TEST SITE
- Area of exposure: ~6.25 cm2
- % coverage: not stated
- Type of wrap if used: site of application covered with linen cloth which adhered to a synthetic film glue; bandage wrapped several times around the trunk providing complete occlusion
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, at end of exposure period
- Time after start of exposure: 4 hours
SCORING SYSTEM: Qualitative and quantitative assessment using Draize method - erythema/eschar and oedema, both scored on a scale of 0-4; also occurrence of further reactions of the skin (e.g. corrosive effects) and clinical signs (indicating systemic toxicity)
Irritation index calculated from sum of mean values of individual scores at the 4 observation times for erythema/eschar and for oedema; graded using modification of the method of Gilman et al., 1983- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: All time points: 1, 24, 48 and 72 hours, 4 and 6 days
- Score:
- ca. 0
- Max. score:
- 8
- Irritant / corrosive response data:
- Erythema/eschar: 0 at all time points in all animals
Oedema: 0 at all time points in all animals.
Corrosion: no effects noted
Corresponding control patch on opposite flank of each animal: no reactions - Other effects:
- No systemic effects observed.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a guideline study, to GLP, carbonylhydridotris(triphenylphosphane)-rhodium(I) was not irritating to the skin of rabbits following a 4-hr occlusive application.
- Executive summary:
The skin irritation potential of carbonylhydridotris(triphenylphosphane)-rhodium(I) was evaluated in White Russian rabbits in a study conducted according to OECD Test Guideline 404 and to GLP.
The test material (0.5 g, moistened with water) was applied to the shaved dorsal skin of 3 animals, covered for 4 hours (occluded) and washed off. Skin reactions were evaluated 1, 24, 48 and 72 hours after patch removal and, in 1 animal, at 4 and 6 days. No erythema/eschar or oedema was observed at any time point in any animal. No corrosive effects or systemic toxicity was noted. Carbonylhydridotris(triphenylphosphane)-rhodium(I) produced a primary dermal irritation index of 0 and was not irritating to the skin of rabbits under the conditions of the test.
Based on the results of this study, no classification for skin irritation is required according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated but QA inspections on 07-Jan-1991 and 15-Jan-1991 during the experimental phase
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: White Russian (Albino)
- Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: ASTA Pharma AG
- Age at study initiation: male 8 months, females 8 and 10 months
- Weight at study initiation: male 2.74 kg, females 2.90 and 3.17 kg
- Housing: stainless steel cages with grating floor, type ASTA, 48.5 cm (l) x 40 cm (b) x 36.5 cm (h); 1/cage
- Diet (e.g. ad libitum): ~120 g/animal per day; standard diet, Ssniff K, special diet for rabbits
- Water (e.g. ad libitum): municipal water supply, using an automatic drinking water system with drinking nipples, ad libitum
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-23
- Humidity (%): 40-55
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: Not stated but QA inspections on 07-Jan-1991 and 15-Jan-1991 during the experimental phase- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The other eye of each animal was not treated and acted as a control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.038 or 0.032 g (approximate volume 0.1 ml)
- Concentration (if solution): not applicable
VEHICLE: none - Duration of treatment / exposure:
- Treated eyes not rinsed but physiological processes would be expected to result in the removal of the test substance
- Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not done
- Time after start of exposure: not applicable
SCORING SYSTEM: Observations made at 1, 24, 48 and 72 after application of test material; signs of irritation assessed qualitatively and quantitatively using Draize scale - cornea (opacity 0-4, area involved 1-4), iris (0-2) and conjunctiva (redness 0-3, chemosis 0-4, discharge 0-3); irritation index calculated as the sum of these scores (0-110); graded according to Gilman et al., 1983
TOOL USED TO ASSESS SCORE: Cliptrix pencil light- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hours
- Score:
- 2
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hours
- Score:
- 2.3
- Max. score:
- 20
- Reversibility:
- fully reversible within: 72 hours
- Irritant / corrosive response data:
- Overall irritation index: 2;
Cornea - opacity and area involved: 0 for all 3 animals at all 4 time points;
Iris: 0 for all 3 animals at all 4 time points;
Conjunctiva - redness - 1, 24, 48 and 72 hours: 1, 2, 1 and 0 (#1), 1, 1, 0, 0 (#2), 0, 1, 1 0 (#3);
Conjunctiva - chemosis: 0 for all 3 animals at all 4 time points;
Conjunctiva - discharge: 2 for all 3 animals at 1 hour, 0 for all 3 animals at all other time points;
No effects in untreated eye of each animal - Other effects:
- No systemic toxicity; no effect on general condition of animals
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a guideline study, to GLP, carbonylhydridotris(triphenylphosphane)-rhodium(I) was not irritating to rabbit eyes following instillation of 0.038 or 0.032 g (volume 0.1 mL) of the test material to the conjunctival sac of 3 animals.
- Executive summary:
The eye irritation potential ofcarbonylhydridotris(triphenylphosphane)-rhodium(I) was evaluated in White Russian rabbits in a study conducted in accordance with OECD Test Guideline 405 and to GLP. A quantity of 0.038 or 0.032 g (volume 0.1 mL) of the test material was placed in the conjunctival sac of 3 animals. The other eye of each animal was not treated and acted as a control. The treated eyes were evaluated at 1, 24, 48 and 72 hr after application and scored for irritation of the cornea, iris and conjunctiva according to the Draize system.
No effects were seen on the cornea or iris of any animal at any time point. Slight or moderate redness was seen in the conjunctivae of all animals, but this had reversed after 72 hr. Moderate conjunctival discharge was seen in all animals at 1 hr, but this had reversed after 24 hr. No corrosive or systemic effects were noted.
Based on the results of this study, no classification for eye irritation is required according to EU CLP criteria (EC 1272/2008).
Reference
Table 1: Individual irritation scores
Ocular lesions | Time after exposure/hr | Draize grade | ||
Animal 1 | Animal 2 | Animal 3 | ||
Corneal opacity | 1 | 0 | 0 | 0 |
24 | 0 | 0 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 | |
Corneal area | 1 | 0 | 0 | 0 |
24 | 0 | 0 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 | |
Iris | 1 | 0 | 0 | 0 |
24 | 0 | 0 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 | |
Conjunctival redness | 1 | 1 | 1 | 0 |
24 | 2 | 1 | 1 | |
48 | 1 | 0 | 1 | |
72 | 0 | 0 | 0 | |
Conjunctival chemosis | 1 | 0 | 0 | 0 |
24 | 0 | 0 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 | |
Conjunctival discharge | 1 | 2 | 2 | 2 |
24 | 0 | 0 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 |
EU criteria: classification in category 2 applies when a positive response is seen in >=2/3 treated animals at >=1 for cornea and/or >=1 for iris and/or >=2 conjunctival redness and/or >=1 for conjunctival oedema, calculated as a mean score at 24, 48 and 72 hours
This calculation produces mean values of 0 for cornea for all 3 animals, 0 for iris for all 3 animals, 1, 0.3 and 0.7 for conjunctival redness for the 3 animals respectively, 0 for conjunctival discharge; therefore category 2 does not apply and the test material is classified as non-irritant by EU criteria
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant irritation/corrosion human data were identified.
The skin irritation potential of carbonylhydridotris(triphenylphosphane)-rhodium(I) was evaluated in White Russian rabbits in a study conducted according to OECD Test Guideline 404 and to GLP. The test material (0.5 g, moistened with water) was applied to the shaved dorsal skin of 3 animals, covered for 4 hours (occluded) and washed off. Skin reactions were evaluated 1, 24, 48 and 72 hours after patch removal and, in 1 animal, at 4 and 6 days. No erythema/eschar or oedema was observed at any time point in any animal. No corrosive effects or systemic toxicity was noted. Carbonylhydridotris(triphenylphosphane)-rhodium(I) produced a primary dermal irritation index of 0 and was not irritating to the skin of rabbits under the conditions of the test (Zechel, 1990).
The eye irritation potential ofcarbonylhydridotris(triphenylphosphane)-rhodium(I) was evaluated in White Russian rabbits in a study conducted in accordance with OECD Test Guideline 405 and to GLP. A quantity of 0.038 or 0.032 g (volume 0.1 mL) of the test material was placed in the conjunctival sac of 3 animals. The other eye of each animal was not treated and acted as a control. The treated eyes were evaluated at 1, 24, 48 and 72 hr after application and scored for irritation of the cornea, iris and conjunctiva according to the Draize system. No effects were seen on the cornea or iris of any animal at any time point. Slight or moderate redness was seen in the conjunctivae of all animals, but this had reversed after 72 hr. Moderate conjunctival discharge was seen in all animals at 1 hr, but this had reversed after 24 hr. No corrosive or systemic effects were noted. Carbonylhydridotris(triphenylphosphane)-rhodium(I) was not irritating to the eyes of rabbits under the conditions of the test (Berthold, 1991b).
No relevant respiratory tract irritation data were identified.
Justification for selection of skin irritation / corrosion endpoint:
OECD guideline study, and the only skin irritation study available.
Justification for selection of eye irritation endpoint:
OECD guideline study, and the only eye irritation study available.
Justification for classification or non-classification
Based on the results of the available skin and eye irritation studies in rabbits, there is no requirement to classify carbonylhydrotris(triphenylphosphine)rhodium for skin or eye irritation according to EU CLP criteria (EC 1272/2008).
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