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EC number: 203-166-4 | CAS number: 104-01-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTIS study report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Summary of toxicity studies for 4-Methoxyphenyl-Acetic Acid (MPAA)
- Author:
- National Technical Information Service
- Year:
- 1 991
- Bibliographic source:
- National Technical Information Service, OTS0530656-1 (1991)
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity studies of (4-methoxyphenyl) acetic acid were carried out on ten new Zealand rabbits(Male and female) under occlusive wrapping to determine the LD50.
- GLP compliance:
- not specified
- Test type:
- other: Acute dermal
- Limit test:
- yes
Test material
- Reference substance name:
- 4-methoxyphenylacetic acid
- EC Number:
- 203-166-4
- EC Name:
- 4-methoxyphenylacetic acid
- Cas Number:
- 104-01-8
- Molecular formula:
- C9H10O3
- IUPAC Name:
- 2-(4-methoxyphenyl)acetic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): 4-methoxyphenyl acetic acid (MPAA)
- Molecular formula (if other than submission substance): C9-H10-O3
- Molecular weight (if other than submission substance): 166.175
- Smiles notation (if other than submission substance): c1(ccc(OC)cc1)CC(O)=O
- InChl (if other than submission substance): 1S/C9H10O3/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H, 6H2, 1H3, (H,10,11)
- Substance type: Organic
- Physical state: Solid
Purity-100%
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):(4-methoxyphenyl) acetic acid
- Molecular formula: C9H10O3
- Molecular weight: 166.175 g/mole
- Substance type: Organic
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure:no data
- % coverage:no data
- Type of wrap if used:occlusive wrapping with absorbent pad - Duration of exposure:
- 24 hrs
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: hourly for first four hours and then twice daily.
- Necropsy of survivors performed: yes
- Frequency of observations and weighing: Twice daily
- Other examinations performed :Mortality, clinical signs, skin Condition and gross pathology were examined. - Statistics:
- no data
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No effect on survival observed
- Mortality:
- No mortality were observed in treated rabbits at 2000 mg/kg bw
- Clinical signs:
- other: Systemic clinical signs were minimal and consisted of abnormal stools in three animals during the first or second day of study
- Gross pathology:
- No macroscopic adverse effects were observed on necropcies.
- Other findings:
- Skin reaction: Erythema and edema were observed in 3 animals which are free of dermal irritation 5 days of treatment.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- LD50 was considered to be > 2000 mg/kg bw when New Zealand White male and female rabbits were treated with (4-methoxyphenyl) acetic acid under an occlusive wrapping for 24 hours.
- Executive summary:
In a acute dermal toxicity study, New Zealand White 5 male and 5 female rabbits were treated with 4-methoxyphenylacetic acid in the concentration of 2000 mg/kg under an occlusive wrapping for 24 hours. No mortality were observed in treated rabbits at 2000 mg/kg bw. Systemic clinical signs were minimal and consisted of abnormal stools in three animals during the first or second day of study and Weight gain during study were observed in all the treated rabbits at 2000 mg/kg bw. Erythema and edema were observed in 3 animals which are free of dermal irritation 5 days of treatment and no macroscopic adverse effects were observed in necropsies. Therefore, LD50 was considered to be > 2000 mg/kg bw when New Zealand White male and female rabbits were treated with 4-methoxyphenylacetic acid under an occlusive wrapping for 24 hours.
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