Registration Dossier
Registration Dossier
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EC number: 201-221-7 | CAS number: 79-72-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4-aminotoluene-2-sulphonanilide
- EC Number:
- 201-221-7
- EC Name:
- 4-aminotoluene-2-sulphonanilide
- Cas Number:
- 79-72-1
- Molecular formula:
- C13H14N2O2S
- IUPAC Name:
- 5-amino-2-methyl-N-phenylbenzene-1-sulfonamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- weight: 133-160 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Doses:
- 316.3 mg/kg bw398.1 mg/kg bw502 mg/kg bw631 mg/kg bw794.3 mg/kg bw1253 mg/kg bw1585 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 577.7 - <= 784.7 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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