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EC number: 604-351-6 | CAS number: 143390-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 165-4 (Laboratory Studies of Pesticide Accumulation in Fish)
- GLP compliance:
- yes
Test material
- Reference substance name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- EC Number:
- 604-351-6
- Cas Number:
- 143390-89-0
- Molecular formula:
- C18 H19 N O4
- IUPAC Name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- Details on test material:
- - Name of test material (as cited in study report): BAS 490F
- Physical state: white solid
- Analytical purity: 99.6%
- Lot No.: 39/149-1
- Radiochemical purity: 97%
- Specific activity: 1117.4 MBq/mmol, 30.2 mCi/mmol adjusted to 10400 dpm/µg
- Locations of the label: Benzyl ring (B-label)
Constituent 1
- Radiolabelling:
- yes
Sampling and analysis
- Details on sampling:
- - Sampling intervals/frequency for test organisms: fish were randomly sampled (during exposure: 10 fish on Day 0, 14, 28, 5 fish on Day 3, 7, 21; during depuration: 3 fish on Day 1, 3, 7, 10, 14
- Sampling intervals/frequency for test medium samples: ca. 500 ml prior adding the fish, after 3, 7, 14, 21, 28 days during exposure period and on the first and last day of depuration; ca. 50 ml were taken on the other days of exposure
- Details on sampling and analysis of test organisms and test media samples:
- Sampling of test organisms: after sampling each fish was blotted dry, separated into viscara and fillet, weighted and stored <= 15 °C
- Extraction of radioactivity from fish samples: from viscera (4-15 g) and fillet (9-24 g) from Days 21 and 28
- Extraction of lipid: pooled samples of viscera and fillet from control fish taken at 0, 14, 28 days of the exposure period
- Extraction of tank water samples: ca. 300 ml for determination of the hydraulic stability of 14C BAS 490F on Days 0, 3, 7, 14, 21 and 28 of exposure
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Parkwood Trout Farm, Kent, UK
- Age at study initiation: ca. 1 year
- Length at study initiation: 5.1 ± 0.5 cm
- Feeding during test
- Food type: commercial trout pellets (BP Mainstream Fry Pellet No. 2; SDS Diets Services, Witham, Essex, UK)
- Amount: to repletion
- Frequency: twice daily
ACCLIMATION
- Acclimation period: 2 weeks
- Acclimation conditions: fiberglass tanks containing 300 L water (loading <1 fish per litre), temperature of 14 ± 1° C, aerated to give > 9.7 mg O2/L, dechlorinated tap water was renewed by a continuous flow system
Study design
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 28 d
- Total depuration duration:
- 14 d
Test conditions
- Test temperature:
- 13- 14 °C
- pH:
- 7.6 - 7.8
- Dissolved oxygen:
- 9.8 - 10.1 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, total volume, fill volume: glass aquaria, ca.100 L, 100 L
- Aeration: >= 10 mg/O2/L
- Renewal rate of test solution (flow rate): 1440 L/vessel/day
- No. of organisms per vessel: ca. 50
- No. of vessels per concentration (replicates): 1
- No. of vessels per control: 1
- Biomass loading rate: < 4 g fish/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated water (by addition of sodium thiosulphate and passage through activated carbon
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light, 8 hours darkness
- Feeding: twice daily to repletion
PRELIMINARY STUDY
- Reason for the preliminary study: to confirm the steady state
- Test concentration: 0.025 mg/L - Nominal and measured concentrations:
- Nominal test concentration: 0.025 mg/L
Results and discussion
Lipid contentopen allclose all
- Lipid content:
- 4.02 %
- Time point:
- start of exposure
- Remarks on result:
- other: referring to total fish (viscera=5.95%; fillet=3.07%)
- Lipid content:
- 4.48 %
- Time point:
- other: after 14 days
- Remarks on result:
- other: referring to total fish (viscera =8.43%; fillet=2.33)
- Lipid content:
- 7.65 %
- Time point:
- end of exposure
- Remarks on result:
- other: refered to total fish (viscera=7.65%; fillet=2.34%)
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- 220
- Basis:
- other: whole fish
- Remarks on result:
- other: mean BCF for 7-28 days
- Remarks:
- Conc.in environment / dose:25 µg/L
- Type:
- BCF
- Value:
- 430
- Basis:
- other: viscera
- Remarks on result:
- other: mean BCF for 7-28 days
- Remarks:
- Conc.in environment / dose:25 µg/L
- Type:
- BCF
- Value:
- 52
- Basis:
- edible fraction
- Remarks on result:
- other: mean BCF for 7-28 days
- Remarks:
- Conc.in environment / dose:25 µg/L
Depurationopen allclose all
- Elimination:
- yes
- Parameter:
- other: DT50 (0-3 days) for total fish
- Depuration time (DT):
- 0.37 d
- Elimination:
- yes
- Parameter:
- other: DT50 (3-10days) for total fish
- Depuration time (DT):
- 3.4 d
- Details on kinetic parameters:
- - Plateau during exposure: 5-6 µg equiv/g during 3-28 days of exposure
- Indication of biphasic kinetics: during depuration - Metabolites:
- BAS 490F, BF 490-4, F2, BF 490-1, 242010, BF 490-9, BF 490-2
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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