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EC number: 700-253-3 | CAS number: 115258-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-09-03 to 2010-11-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, study is performed according to OECD and EU guidelines, no deviation from study plan.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide
- EC Number:
- 700-253-3
- Cas Number:
- 115258-10-1
- Molecular formula:
- C15H37NO4Si4
- IUPAC Name:
- N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: one: 29 µg/L (n = 4)
- Duplicate samples from the freshly prepared test medium of the only test concentration and the controls were taken at the start of the test.
- For the determination of the stability of the test item under the test conditions and of the maintenance of the test item concentration during the test period, duplicate samples from the test medium of the only test concentration and the controls were collected at the end of the test (after 48 hours).
- All samples were measured directly at the day of sampling
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method:acc. to OECD 23 with solvent
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Dimethylformaide
- Concentration of vehicle in test medium (stock solution and final test solution): stock soluition: 290 mg/L
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain: Clone 5
- Source:
- Age at study initiation (mean and range, SD): 2.5 to 18.75 hours
- Method of breeding: continous laboratory culture
- Feeding during test: no
- Food type: not applicable
- Amount: not applicable
- Frequency: not applicable
ACCLIMATION
- Acclimation period: not necessary, laboratory breed stock
- Acclimation conditions (same as test or not): see above
- Type and amount of food: Desmodesmus
- Feeding frequency: all working days
- Health during acclimation (any mortality observed): not applicable
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- no
Test conditions
- Hardness:
- Reconstituted Water, (Elendt M4):
Water Hardness: 2.5 mmol/L (= 250 mg/L) as CaCO3
Alkalinity: 0.9 mmol/L - Test temperature:
- 20 to 21 °C at test start;
20 °C at test end - pH:
- 8.1 at test start;
7.6 to 7.7 at test end; and thus the pH-value did not vary by more than 1.5 units - Dissolved oxygen:
- 8.9 to 9.0 mg/L at test start;
8.3 mg/L at test end - Nominal and measured concentrations:
- see block "additional information on results"
- Details on test conditions:
- TEST SYSTEM
- Test vessel: beaker, 100 ml
- Material, size, headspace, fill volume: 60 ml
- Aeration: no
- Type of flow-through (e.g. peristaltic or proportional diluter): not applicable
- Renewal rate of test solution (frequency/flow rate): no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
- Culture medium different from test medium: no
- Intervals of water quality measurement: no data
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16/8 l/d
- Light intensity: 330 - 400 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : immobility
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not applicable
- Justification for using less concentrations than requested by guideline: low water solubility
- Range finding study: yes
- Test concentrations: 1-10-100 mg/L
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- no
- Remarks:
- historical data
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 29 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 29 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 29 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no
- Observations on body length and weight: no data
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: yes, in the range fining test. Therefore a solvent and lower concentrations were used in the definite test - Results with reference substance (positive control):
- - Results with reference substance valid, as determined by historical and regularily conducted study
- Mortality: control: 0
- EC50/LC50: 1.59 (24 h) and 1.37 mg/L (48 h) - Reported statistics and error estimates:
- not applicable due to no observed immobility
Any other information on results incl. tables
Summary of Biological Results |
||
Nominal Concentration |
% of immobilised Daphnia after |
|
[µg test item/L] |
24 hours |
48 hours |
Control |
0 |
0 |
Solvent Control |
0 |
0 |
29 |
0 |
0 |
EC50[µg/L]: |
> 29 |
> 29 |
95 % confidence values [µg/L]: |
n.d. |
n.d. |
NOEC [µg/L]: |
≥ 29 |
³29 |
LOEC [µg/L]: |
> 29 |
> 29 |
Values refer to nominal test concentrations. |
Analytical Results
sample description µg/L | geometric % of nominal | n |
control | n.a. | 2 |
29 | 48 | 4 |
At the start of the test 92 % of the nominal test concentration was found. After 48 hours test duration, 27 % of the nominal value was determined. All reported results refer to nominal concentrations. |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The toxic effect of the test item N-[3-tris(trimethylsilyloxy) silylpropyl]prop-2-enamide to Daphnia magna was assessed in a static limit-test. The 48-hour NOEC was determined to be > 29 µg test item/L. The 48-hour LOEC was determined to be > 29 µg test item/L The 48-hour EC50 value was determined to be > 29 µg test item/L.
- Executive summary:
The only concentration tested was nominal 29 µg test item/L(in 100 mg Dimethylformamide/L), a solvent control (100 mg Dimethylformamide/L) and a control. Additionally; a control was tested in parallel (test water without addition of the test item). Thus a limit test was performed in accordance with OECD Guideline 202 to demonstrate that the test item has no toxic effect on the test animals up to this concentration. No mortality or immobility was observed after 24 and the 48 h. In conclusion under test conditions no toxicity of the test item to freshly hatched daphnia was observed.
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