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EC number: 205-793-9 | CAS number: 151-56-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accidental exposure.
Data source
Reference
- Reference Type:
- publication
- Title:
- Accidental Exposure to Ethylenimine and N-Ethylethylenimine Vapors
- Author:
- Weightman J, Hoyle JP
- Year:
- 1 964
- Bibliographic source:
- JAMA 189: 543-545.
Materials and methods
- Study type:
- poisoning incident
- GLP compliance:
- no
Test material
- Reference substance name:
- Aziridine
- EC Number:
- 205-793-9
- EC Name:
- Aziridine
- Cas Number:
- 151-56-4
- Molecular formula:
- C2H5N
- IUPAC Name:
- aziridine
Constituent 1
Method
- Type of population:
- other: students
- Subjects:
- - Number of subjects exposed: 5
- Sex: male
- Age: young - Ethical approval:
- not applicable
- Route of exposure:
- inhalation
- Reason of exposure:
- accidental
- Details on exposure:
- The subjects were exposed to approximately 20 g of ethylenimine as well as other substances: N-ethylethylenimine, ammonia and isopentane.
- Examinations:
- - Urine analysis: daily urinalyses
- Haematology: blood counts, blood urea
- Lung function parameters: yes
- Other: Electrocardiograms (ECG), chest x-rays, nitrogen (BUN), serum electrolytes (Na, Cl, K), carbon dioxide combining power (C02), and serum
glutamic oxalacetic transaminase (SGOT): yes - Medical treatment:
- Treatment consisted of a compound of hydrocortisone acetate and neomysin sulfate (Neo-Cortef), decongestants, antihistamine expectorant, and anti-inflammatory enzyme therapy. Hydration included large amounts of orange juice and carbonated beverages.
In one patient, antibiotics and intermittent positive-pressure treatments were added to the regime.
Results and discussion
- Clinical signs:
- Lacrimation, irritation of the eyes, vomiting and coughing, soreness of the throat, inflammation of the upper respiratory tract.
- Results of examinations:
- - Urine analysis: mild albuminuria with a few red cells in the urine
- Haematology: early hemoconcentration, manifested by hemoglobin increases up to 20 gm; sporadic eosinophilic response during the first two weeks
- Lung function parameters: timed vital capacity showed impairment in 4 patients but all chest x-rays were normal.
- Other: macular eruptions, presumably due to drugs used in therapy, suggesting that sensitization was increased by the chemical vapors; elevated cephalin flocculation tests by the tenth day indicating some inflammatory effect on the liver; electrocardiographic changes; the eyes and upper
respiratory system of each patient exhibited extensive inflammatory reaction; corrosive burn ulcération of the vocal cords in one patient and of the nasal cavity in other patient
No corneal ulcerations were found and no permanent visual impairment was encountered. - Effectivity of medical treatment:
- Hemoglobin increases returned to normal limits within one week.
The eyes and upper respiratory system of each patient exhibited extensive inflammatory reaction which required several months for recovery.
Patients 4 and 5 showed improvement, but not normal results, in timed vital capacity at the end of three months as well as residual inflammation of the conjunctivae. - Outcome of incidence:
- Three-month followup revealed apparent complete recovery in patients 1, 2, and 3.
Patients 3, 4 and 5 were unable to continue academic work for one semester because of ocular inflammation.
Any other information on results incl. tables
No more available data on the results.
Applicant's summary and conclusion
- Conclusions:
- Exposure to ethyleneimine causes conjunctivitis, upper and lower respiratory tract inflammation, transitory polycythemia, leukocytosis, eosinophilia, and albuminuria.
- Executive summary:
Five college students in Lewisburg, were accidentally exposed to two highly toxic chemicals, ethylenimine and N-ethylethylenimine, for two hours in a poorly ventilated fraternity-house room. Their complaints, delayed in onset from 3 to 7 1/2 hours after exposure, were severe soreness of the throat, severe eye irritation, vomiting, and coughing. Consistent clinical findings were conjunctivitis, upper and lower respiratory tract inflammation, transitory polycythemia, leukocytosis, eosinophilia, and albuminuria. Treatment included antihistamines, hydration, topical and systemic steroids, antibiotics, cough preparations, and enzyme therapy. All five students were free of symptoms within six months.
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