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Diss Factsheets
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EC number: 603-525-9 | CAS number: 131860-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Eye irritation: Mild irritant, average scores day 1-3: cornea 0, iris 0, erythema 0.45, chemosis 0.22 (Robinson)
Skin irritation: no skin irritation was noted in acute dermal toxicity (cf. 7.2.3), hence according to Regulation (EC) 1907/2006, Annex VII and VIII, 8.1, column 2, in vitro and in vivo skin irritation testing is not required.
Respiratory irritation: slight signs of irritation noted in acute inhalation toxicity (cf. 7.2.2)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Eye
For this endpoint the summarised result of one study (Robinson) is available, which was conducted under GLP. While the full study report is not available, the results are sufficiently detailed and unambiguous as to be suitable for classification and labeling. Average scores (day 1-3): cornea 0, iris 0, erythema 0.45, chemosis 0.22.
Based on the given scores the assessment “not irritating” is carried forward for classification and labeling.
Skin
No skin irritation was noted in a limit-dose acute dermal toxicity study (see 7.2.3). Hence, according to Regulation (EC) 1907/2006, Annex VII and VIII, 8.1, column 2, in vitro and in vivo skin irritation testing is not required.
Respiratory
Slight transient respiratory irritant effects were noted in 2/3 males and 0/3 females in a 1-hour acute inhalation toxicity study (see 7.2.2). Because the study was performed with a maximum concentration < 5 mg/L, and extrapolated from 1-hour exposure data, the result is not considered to be conclusive for classification and labeling.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
The available data on Eye Irritation is considered reliable and suitable for classification and labeling.
Based on the result, the substance does not meet the criteria for classification under the Directive 2001/59/EC, Annex VI, 3.2.6.2. as well as the criteria in the Regulation (EC) No. 1272/2008, Annex I, Part 3, 3.3.2.
The available information on Acute Dermal Toxicity are considered reliable for the classification and labeling of the substance in term of Skin Corrosion/Irritation.
Based on the result, the substance does not meet the criteria for classification under the Directive 2001/59/EC, Annex VI, 3.2.6.1. as well as the criteria in the Regulation (EC) No. 1272/2008, Annex I, Part 3, 3.2.2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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