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EC number: 931-286-3 | CAS number: 12068-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-07-30 - 2009-10-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
- Type of study / information:
- Determination of the resorption in the lung of Hercynite in order to determine the bio-accessible parts.
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccessibility testing of Cobalt compounds", Woodhall Stopford et al., J. Environ. Monit. 5, 2003, p. 675 - 680.
- Deviations:
- yes
- Remarks:
- Temperature was 37 ± 1.5 °C instead of 37 ± 1 °C. As virtually no dissolution of the test item was observed, the deviation was assessed as uncritical.
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccessibility testing of Cobalt compounds", Woodhall Stopford et al., J. Environ. Monit. 5, 2003, p. 675 - 680.
- Deviations:
- yes
- Remarks:
- Shaking was performed for two hours only in order to prevent too high temperatures in the incubator. As no dissolution was observed in the first flasks, this is considered as uncritical concerning the outcome of the study.
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccessibility testing of Cobalt compounds", Woodhall Stopford et al., J. Environ. Monit. 5, 2003, p. 675 - 680.
- Deviations:
- yes
- Remarks:
- Because of presence of KCl in synth. lung fluid, no addition of KCl before measurement via AAS was necessary.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- dialuminium iron tetraoxide, spinel type
- EC Number:
- 924-056-9
- Cas Number:
- 1302-61-0
- Molecular formula:
- Al2FeO4
- IUPAC Name:
- dialuminium iron tetraoxide, spinel type
Constituent 1
Results and discussion
Any other information on results incl. tables
1.1 Calculation of Mobilised Mass
The mobilised masses of the two elements were calculated from
wi,mob = (Ci * V)/mE
with
wi,mob = mobilised part in µg/g test item per element
Ci = measured element concentration in µg/L
V = total volume in L of the aqueous phase (0.05 L in all samples)
mE = weight of used test item (nominal: 1.0 g, real weights were used for calc.)
1.2 Calculation of Bioaccessibility
Bioaccessibility was calculated as
Ri = (wi,mob * 100%)/wi,total
with
Ri = bioaccessible part in %
wi,mob = mobilised part in µg/g test item per element
wi,total = total part of the respective element in the test item in µg/g
1.3 Bioaccessible Parts (Al-Content)
The bioaccessible part Riat each sampling date as calculated from the measured Al concentrations in the solutions, the weights used and the Al content of the test item is presented in the following table:
Bioaccessible Part Al
Flask |
Weight |
Sampling Time |
Measured value for Al |
Measured value for Al |
wi,mob |
Ri |
|
g |
h |
mg/L |
µg/L |
µg/g |
% |
1* |
1.0700 |
2 |
< LOQ |
< LOQ |
< LOQ |
<4.523 * 10-5 |
2* |
1.0405 |
2 |
< LOQ |
< LOQ |
< LOQ |
<4.652 * 10-5 |
3 |
1.0762 |
5 |
0.253 |
0.256 |
11.9 |
4.599* 10-5 |
4* |
1.0418 |
5 |
< LOQ |
< LOQ |
< LOQ |
<4.646 * 10-5 |
5 |
1.0653 |
24 |
0.442 |
442 |
20.74 |
8.031 * 10-5 |
6 |
1.0947 |
24 |
0.390 |
390 |
17.82 |
6.902 * 10-5 |
7 |
1.0057 |
72 |
0.569 |
569 |
28.30 |
1.096 * 10-4 |
8 |
1.0105 |
72 |
0.473 |
473 |
23.42 |
9.070 * 10-5 |
Riwas determined from LOQ of Al (0.25 mg/l)
The mobilised masses of the measured elements and the bioaccessibilities summary after 72 h are presented in the following table:
Bioaccessible Part Al, summary
Parameter |
Mean |
Standard Deviation |
Relative Standard Deviation (%) |
Mobilised mass of test item in µg/g |
25.86 |
3.45 |
13% |
Bioaccessibility in % |
1.00 * 10-4 |
1.33 * 10-5 |
13% |
1.1 Bioaccessible Parts (Fe-Content)
The bioaccessible part Ri at each sampling date as calculated from the measuredFeconcentrations in the solutions, the weights used and the Fe content of the test item is presented in the following table:
Bioaccessible PartFe
Flask |
Weight |
Sampling Time |
Measured value for Fe |
Measured value for Fe |
wi,mob |
Ri* |
|
g |
h |
mg/L |
µg/L |
µg/g |
% |
1 |
1.0700 |
2 |
< LOQ |
< LOQ |
< LOQ |
<1.336 * 10-6 |
2 |
1.0405 |
2 |
< LOQ |
< LOQ |
< LOQ |
<1.374 * 10-6 |
3 |
1.0762 |
5 |
< LOQ |
< LOQ |
< LOQ |
<1.328 * 10-6 |
4 |
1.0418 |
5 |
< LOQ |
< LOQ |
< LOQ |
<1.372 * 10-6 |
5 |
1.0653 |
24 |
< LOQ |
< LOQ |
< LOQ |
<1.342 * 10-6 |
6 |
1.0947 |
24 |
< LOQ |
< LOQ |
< LOQ |
<1.306 * 10-6 |
7 |
1.0057 |
72 |
< LOQ |
< LOQ |
< LOQ |
<1.422 * 10-6 |
8 |
1.0105 |
72 |
< LOQ |
< LOQ |
< LOQ |
<1.415 * 10-6 |
* Riwas determined from LOQ of Fe (0.0094 mg/l)
Applicant's summary and conclusion
- Conclusions:
- The bioaccessibility of the test item in the lung is 1.00 *10-4% (Al-content) and less then 1.422 * 10-6% (Fe-content).
- Executive summary:
All replicates shows good correspondance. Poor dissolution of the test item was observed. The bioaccessibility of the test item in the lung is 1.00 *10-4% (Al-content) and less then 1.422 * 10-6% (Fe-content).
The deviation between Fe and Al shows, that the test item is perhaps not a well defined compound but rather a mixed crystal, where some parts are more soluble as others.
The mobilised masses of the measured elements and the bio-accessibilities after 72 hours incubation are presented in the following table:
Parameter
Mean
Standard Deviation
Relative Standard Deviation (%)
Mobilised mass of test item (Al) in µg/g
25.86
3.45
13%
Bioaccessibility (Al) in %
1.00 * 10-04
1.34* 10-05
13%
The values of Fe were below LOQ, therefore Rifor Fe is less then 1.422 * 10-6% (value determined from LOQ 0.0094 mg/L).
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