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Reaction mass of sodium aqua[5-{[2-hydroxy-4-(hydroxy-kO)-5-{[2-(hydroxy-kO)-3,5-dinitrophenyl]diazenyl}phenyl]diazenyl}naphthalene-1-sulfonato(3-)]ferrate(1-) and sodium diaqua(chloro)[5-{[2-hydroxy-4-(hydroxy-kO)-5-{[2-(hydroxy-kO)-3,5-dinitrophenyl]diazenyl-kN2}phenyl]diazenyl}naphthalene-1-sulfonato(3-)]ferrate(1-)
EC number: 700-899-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- other: read across from analogue substance
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- Internal BASF method was used, which were in large parts equivalent to method described in OECD guideline 403
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Analogue Substance_01
- IUPAC Name:
- Analogue Substance_01
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr . K . Thomas GmbH, 7950 Biberach
- Age at study initiation: 8 weeks
- Weight at study initiation: mean 245 g (males), 161 g (females)
- Housing: five per cage in stainless stelle wire mesh cages, Type D-III
- Diet (e.g. ad libitum): KLIBA Labordiät Ratte/Maus A 343 10 mm Pellet, Klingentalmühle AG, CH-4303 Kaiseraugst; ad libitum
- Water (e.g. ad libitum): drinking water; ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: INA 20 head/nose inhalation system ( glass/steel construction, BASF AG);
- Exposure chamber volume: ca. 55 l
- Method of holding animals in test chamber: the animals sit in tubes and their snouts project into the inhalation chamber
- Source and rate of air: 1500 l/h of compressed air through the injector and 1500 l/h of conditioned air as dilution air
- Method of conditioning air: via a central airconditioning unit
- System of generating particulates/aerosols: the substance to be tested was transformed into a dust aerosol by means of a automatic vibrator, and was passed into the inhalation system
- Method of particle size determination: gravimetrically
- Temperature, humidity, pressure in air chamber: 19 - 25°C, 10% lower than that of the supply air system (excess pressure)
TEST ATMOSPHERE
- Brief description of analytical method used: The preweighed filter was placed in a filtration equipment. A volume of dust aerosol characterized by a flow-limiting nozzle was passed through the filter by means of a vacuum compressed air pump. The dust concentration (mg/l) was calculated from the difference between the preweight of the filter and the weight of the filter after sampling with reference to the sample volume.
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: dust proportion of 83% .
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 4.2 µm / 2.8 - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetrically
- Duration of exposure:
- 4 h
- Concentrations:
- 5.2 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: body weights were checked before the start of the study, after 7 days and at the end of the observation period. The animals were checked for clinical signs on each working day. The lethality was checked daily.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- The statistical evaluation of the concentration response relationship was based on the binomial test (Wittig, H.: Mathematische Statistik 1974, (Mathematical Statistics), pages 32 to 35) according to the Tables issued by the BASF computer center.
The particle size determination was based on mathematical and graphical evaluation methods for particle measurements (Silverman, L .: Particle Size Analysis in Industrial Hygiene, 1971, pp. 235 - 259) and was carried out at the Department of Toxicology of BASF AG.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.2 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: dust
- Mortality:
- No mortality
- Clinical signs:
- other: During exposure: initially attempts to escape, irregular breathing After exposure: nothing abnormal detected
- Body weight:
- Mean body weights (g) on days 0/7/14:
- Males: 245 / 275 / 308
- Females: 161 / 177 / 189 - Gross pathology:
- Nothing abnormal detected in the organs
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The analogue substance was tested for acute toxicity inhalation following internal guidelines similar to OECD 403. This dust inhalation study shows that the LC50 (rat,inhalation) is >5.2 mg/l. No mortality or gross pathological changes were observed.
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