Registration Dossier
Registration Dossier
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EC number: 812-877-4 | CAS number: 1228350-17-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Remarks:
- The study was conducted according to guideline in effect at time of study conduct.
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl methacrylate
- EC Number:
- 218-407-9
- EC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl methacrylate
- Cas Number:
- 2144-53-8
- Molecular formula:
- C12H9F13O2
- IUPAC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl methacrylate
- Details on test material:
- - Purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley CD (Crl: CD® (SD) IGS BR)
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
There were no deaths. There were no signs of systemic toxicity. No abnormalities were noted at necropsy.
The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was estimated as being greater than 2500 mg/kg bodyweight.
Applicant's summary and conclusion
- Interpretation of results:
- other: LD50 > 2500 mg/kg
- Conclusions:
- LD50 > 2500 mg/kg
- Executive summary:
Six fasted female animals were given a single oral dose of undiluted test material, at a dose level of 2000 mg/kg bodyweight. There were no deaths. The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was estimated to be greater than 2500 mg/kg bodyweight.
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