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Diss Factsheets
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EC number: 202-381-0 | CAS number: 94-99-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
During the evaluation of available data, Daphnia magna as well as Poecilia reticulata have been identified as most sensitive species. Based on the above acute LC50 values (below 1 mg/L) and considering the low biodegradability of the test substance, it needs to be classified and labelled as aquatic acute cat 1 (H400 Very toxic to aquatic life) and aquatic chronic cat. 1 (H410 Very toxic to aquatic life with long lasting effects) according to Regulation (EC) No 1272/2008 (CLP).
Additional information
There are several publications available describing the aquatic toxicity in daphnia and fish. Based on the reliability, the publication of Marchini et al. (1999) with daphnids has been identified as trigger for aquatic classification. In the fish publication (Könemann, H., 1981) including Poecilia reticulata (guppy) the determined 14-day EC50 value is 0.234 mg/L additionally supporting the trigger value of the daphnid study. The guppy value is below the LC50 value of the already available acute study of Bayer (96-h LC50 = 2.7 mg/L, zebra fish) showing a higher sensitivity of guppies compared to zebrafish. The 48 hour acute toxicity of alpha 2,4-Trichlorotoluene was further studied under static conditions equivalent to OECD guideline 202. Daphnids were exposed to a minimum of five concentrations (20 animals per concentration). Four replicates were performed for each concentration. The validity criteria were met as the immobilisation in the controls was < 10 % and the dissolved oxygen always maintained above 75 % saturation. A 48-hour LC50 of 0.12 to 0.13 mg/L was determined
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