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Diss Factsheets
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EC number: 202-885-0 | CAS number: 100-74-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1968
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Meets generall accepted scientific standards, well documented and acceptable for assessment. Study similar to OECD guideline 404.
Data source
Reference
- Reference Type:
- publication
- Title:
- Skin Irritation
- Author:
- Japanese government
- Year:
- 2 005
- Bibliographic source:
- OECD SIDS Initial Assessment Report for SIAM21 and OECD Agreed Conclusions
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-ethylmorpholine
- EC Number:
- 202-885-0
- EC Name:
- 4-ethylmorpholine
- Cas Number:
- 100-74-3
- Molecular formula:
- C6H13NO
- IUPAC Name:
- 4-ethylmorpholine
- Test material form:
- liquid
- Details on test material:
- - Alternative names of reference substance: Jeffcat NEM; N-ethylmorpholine; 4-ethylmorpholin; Morpholine, 4-ethyl-
- Molecular formula: C6H13NO
- Molecular weight: 115.17
- SMILES notation: CCN1CCOCC1
- InChl: InChI=1/C6H13NO/c1-2-7-3-5-8-6-4-7/h2-6H2,1H3
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- contact periods were 1, 5, and 15 minutes and 20 hours
- Observation period:
- 24hrs and 8 days post treatment
- Details on study design:
- TEST SITE
- Area of exposure: dorsal region
- % coverage: no data
- Type of wrap if used: occlusive, no further data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: no data
SCORING SYSTEM: table of Draize contained in the OECD guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: after 1 min exposure
- Time point:
- other: 24 hrs
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- other: after 5 min exposure
- Time point:
- other: 24 hrs
- Score:
- 3
- Irritation parameter:
- erythema score
- Basis:
- other: after 15 min exposure
- Time point:
- other: 24 hrs
- Score:
- 3
- Remarks on result:
- other: N2
- Irritation parameter:
- erythema score
- Basis:
- other: after 20 hrs exposure
- Time point:
- other: 24 hrs
- Score:
- 3
- Remarks on result:
- other: N2
- Irritation parameter:
- edema score
- Basis:
- other: after 1 min exposure
- Time point:
- other: 24 hrs
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: after 5 min exposure
- Time point:
- other: 24 hrs
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- other: after 15 min exposure
- Time point:
- other: 24 hrs
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: after 20 hrs exposure
- Time point:
- other: 24 hrs
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- other: after 1 min exposure
- Time point:
- other: 8 days
- Score:
- 3
- Remarks on result:
- other: desquamation
- Irritation parameter:
- erythema score
- Basis:
- other: after 5 min exposure
- Time point:
- other: 8 days
- Remarks on result:
- other: N 2
- Irritation parameter:
- erythema score
- Basis:
- other: after 15 min exposure
- Time point:
- other: 8 days
- Remarks on result:
- other: N 3
- Irritation parameter:
- erythema score
- Basis:
- other: after 20 hrs exposure
- Time point:
- other: 8 days
- Remarks on result:
- other: N 3
- Irritant / corrosive response data:
- Moderate to severe skin irritation was noted at 24 hours post treatment even after short contact periods of 1 or 15 minutes. The lesions aggravated and developed into full thickness necrosis within 8 days post treatment
Any other information on results incl. tables
Skin reaction scores similar to the table contained in OECD guideline 404 after 24 hours or 8 days:
24
hrs 8
days
-----------------------------------------------------------
Erythema
1 minute 2 Desquamation
3
5 minutes 3 N
2
15 minutes 3
/ N 2 N
3
20 hours 3
/ N 2 N
3
-----------------------------------------------------------
Edema
1 minute 0
5 minutes 2
15 minutes 0
20 hours 2
-----------------------------------------------------------
N = necrosis
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- The test substance was considered corrosive category 1 to skin.
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