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EC number: 202-658-6 | CAS number: 98-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: as per below mentioned
- Principles of method if other than guideline:
- In acute toxicity to fish test been performed to evaluate the toxicological effects of chemical 4-Amino-m-toluenesulfonic acid in fish
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-Amino-m-toluenesulfonic acid
- Molecular formula: C7H9NO3S
- Molecular weight: 187.218 g/mol
-Smiles: S(c1cc(c(N)cc1)C)(O)(=O)=O
- InChI: 1S/C7H9NO3S/c1-5-4-6(12(9,10)11)2-3-7(5)8/h2-4H,8H2,1H3,(H,9,10,11)
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Details on sampling:
- No data available
- Vehicle:
- not specified
- Details on test solutions:
- No data available
- Test organisms (species):
- Gambusia affinis
- Details on test organisms:
- TEST ORGANISM
- Common name:Mosquitofish
- Source:Fishes were collected from Stillwater creek in payne country
- Age at study initiation (mean and range, SD):Adult - Test type:
- static
- Water media type:
- brackish water
- Total exposure duration:
- 96 h
- Post exposure observation period:
- no data available
- Hardness:
- no data available
- Test temperature:
- 19-22deg C
- pH:
- 4.4-7.7
- Dissolved oxygen:
- no data available
- Salinity:
- no data available
- Conductivity:
- no data available
- Nominal and measured concentrations:
- no data available
- Details on test conditions:
- TEST SYSTEM
- Test vessel:Cylindrical pyrex jars
- Type (delete if not applicable): open / closed
- Aeration:12 inch high and 12 inchin diameter
- No. of organisms per vessel:10 fishesin 1 aquarium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:Aquaria
- Alkalinity:100 ppm of methyl orange
OTHER TEST CONDITIONS
- Adjustment of pH:pH was lowered slightly less than 6.4
TEST CONCENTRATIONS
- Test concentrations:180,320,560,1000 mg/l - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 375 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 410 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 425 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Details on result
- Other adverse effects control: in 180 mg/l and less the fishes were apparently normal .At 320 mg/l one was dead in 48-h ,2 in 72-h and and fourth in 96-h.At 560 and 1000 mg/l all were dead in 6 hrs only. - Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In short term fish toxicity study the median lethal concentration (LC50) value was observed to be 375 mg/L, 410 mg/L and 425 mg/L for exposure period of 96,48 and 24-hrs respectively when tested in Gambusia affinis fish.
- Executive summary:
In acute toxicity to fish test been performed to evaluate the toxicological effects of chemical 4-Amino-m-toluenesulfonic acid in fish (Gambusia affinis).The chemical was exposed to Gambusia affinis fish with dose concentration of 180,320,560,1000 mg/L with exposure duration of 24,48 and 96 hrs.The mortality was observed in the fish, at 560 and 1000 mg/L all animals were dead in 6 hrs only. Hence,the median lethal concentration (LC50) value was observed to be 375 mg/L, 410 mg/L and 425 mg/L for exposure period of 96,48 and 24-hrs respectively when tested in Gambusia affinis fish based on mortality effect.
Based on this value it can be concluded that the substance 4-amino-3-methylbenzenesulfonic acid is considered to be non-toxic to fish and can be considered to be not classified as per the CLP classification criteria.
Reference
Description of key information
In acute toxicity to fish test been performed to evaluate the toxicological effects of chemical 4-Amino-m-toluenesulfonic acid in fish (Gambusia affinis).The chemical was exposed to Gambusia affinis fish with dose concentration of 180,320,560,1000 mg/L with exposure duration of 24,48 and 96 hrs.The mortality was observed in the fish, at 560 and 1000 mg/L all animals were dead in 6 hrs only.Hence,the median lethal concentration (LC50) value was observed to be 375 mg/L, 410 mg/L and 425 mg/L for exposure period of 96,48 and 24-hrs respectively when tested in Gambusia affinis fish based on mortality effect.
Based on this value it can be concluded that the substance 4-amino-3-methylbenzenesulfonic acid is considered to be non-toxic to fish and can be considered to be not classified as per the CLP classification criteria.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 375 mg/L
Additional information
Four different studies from experimental study using peer reviewed journal and validated predicted model for short term fish toxicity endpoint of target chemical 4-amino-3-methylbenzenesulfonic acid (Cas no. 98-33-9) with relevant read across chemicals which is structurally similar to target chemical are summarized as followed:
First experimental study suggest acute toxicity to fish test been performed to evaluate the toxicological effects of chemical 4-Amino-m-toluenesulfonic acid in fish (Gambusia affinis).The chemical was exposed to Gambusia affinis fish with dose concentration of 180,320,560,1000 mg/L with exposure duration of 24,48 and 96 hrs.The mortality was observed in the fish, at 560 and 1000 mg/L all animals were dead in 6 hrs only.Hence,the median lethal concentration (LC50) value was observed to be 375 mg/L, 410 mg/L and 425 mg/L for exposure period of 96,48 and 24-hrs respectively when tested in Gambusia affinis fish based on mortality effect.
Other predicted data gives assistance to above experimental result i.e predicted model by EPI Suite ECOSAR version 1.10 indicate the 96 hours LC50 was estimated to be 230000 mg/l on Fish for substance 4-amino-3-methylbenzenesulfonic acid (Cas no. 98-33-9) on the basis of mortality effects.
Above both results for target chemical supported by experimental study of read across 4-aminobenzenesulfonic acid (Cas no. 121-57-3) which suggest Toxic effects of test substance 4-amino-benzenesulfonic acid was determined on various fish species like Leuciscus idus, Bruchydunio rerio,Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate for 48 and 96 hrs in static condition and in fresh water. During experiment the lethal concentrations i.e LC0 and LC50 values were found to be 1000 mg/l and 100.4 mg/l respectively. (Chemosphere, Vol. 28, No. 12, pp. 2203.2236, 1994)
Another study for one more structurally similar read across chemical 2-amino-5-methylbenzenesulfonic acid (Cas no. 88-44-8) indicate the toxic effects of test substance 4-aminotoluene-3-sulphonic acid was examined on fish Oryzias latipes for 48 hrs. During experiment the lethal concentration (LC50) was found to be 480 mg/l on the basis of mortality effects.
All available median lethal concentration (LC50) values for fish toxicity in acute exposure is in the range of 375-230000 mg/l which gives common conclusion as target chemical 4-amino-3-methylbenzenesulfonic acid (Cas no. 98-33-9) is considered to be non-toxic to fish and can be considered to be not classified for aquatic environment as per the CLP classification criteria.
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