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EC number: 200-625-0 | CAS number: 66-27-3
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradability of Methyl methanesulfonate (CAS no. 66 -27 -3) is predicted using QSAR toolbox version 3.3 (2017) with logKow as the primary descriptor. Test substance undergoes 29.2% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical Methyl methanesulfonate was estimated to be not readily biodegradable in water.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound Methyl methanesulfonate (CAS No. 66 -27 -3). If released in to the environment, 40.7% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Methyl methanesulfonate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Methyl methanesulfonate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0818%), indicates that Methyl methanesulfonate is not persistent in sediment.
Biodegradation in soil
The half-life period of Methyl methanesulfonate (CAS No. 66 -27 -3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 51.3% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Methyl methanesulfonate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Methyl methanesulfonate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various predicted data for the target compound Methyl methanesulfonate(CAS No. 66-27-3) and supporting weight of evidence studies for its closest read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical Methyl methane sulfonate(CAS No. 66 -27 -3) was estimated.Test substance undergoes 29.2% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemicalMethyl methanesulfonatewas estimated to be not readily biodegradable in water.
In another prediction using the Estimation Programs Interface Suite (EPI suite, 2018), the biodegradation potential of the test compound, Methyl methanesulfonate(CAS No. 66-27-3) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemicalMethyl methanesulfonateis expected to be not readily biodegradable.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2017) for the read across chemical Dimethyl disulfide (CAS no. 624-92-0),biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance Dimethyl disulphide. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance Dimethyl disulfide was determined to be 0% and 4% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, Dimethyl disulphide is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical Methyl methanesulfonate (from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK, 2017), it can be concluded that the test substance Methyl methanesulfonate can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound Methyl methanesulfonate (CAS No. 66 -27 -3). If released in to the environment, 40.7% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Methyl methanesulfonate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Methyl methanesulfonate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0818%), indicates that Methyl methanesulfonate is not persistent in sediment.
Biodegradation in soil
The half-life period of Methyl methanesulfonate (CAS No. 66 -27 -3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 51.3% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Methyl methanesulfonate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Methyl methanesulfonate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance Methyl methanesulfonate can be considered to be not readily biodegradable in nature.
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