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EC number: 215-833-7 | CAS number: 1423-46-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The test item was assessed for short term toxicity to Daphnia according to OECD Guidelines for Testing of Chemicals (April 2004) No 202, "Daphniasp., Acute Immobilisation Test" referenced as Method C.2 of Commission Regulation (EC) No. 440/2008. Based on the time-weighted mean measured test concentrations, the 48 hour EC50 was 11 mg/L with 95 % confidence limits of 9.2 - 12 mg/L. The NOEC was 4.6 mg/L and the LOEC was 8.7 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 11 mg/L
Additional information
The test item was assessed for short term toxicity to Daphnia according to OECD Guidelines for Testing of Chemicals (April 2004) No 202, "Daphniasp., Acute Immobilisation Test" referenced as Method C.2 of Commission Regulation (EC) No. 440/2008.
Preliminary solubility work conducted indicated that it was not possible to obtain a testable solution of the test item using traditional methods of preparation e.g. ultrasonication.
A preliminary media preparation trial indicated that a dissolved test item concentration of approximately 85 mg/L was obtained from a saturated solution method of preparation indicating this to be the limit of water solubility of this item under test conditions.
Following a preliminary range-finding test, twenty daphnids (4
replicates of 5 animals) were exposed to an aqueous solution of the test
item at nominal concentrations of 10, 18, 32, 56 and 100% v/v saturated
solution for 48 hours at a temperature of approximately 20°C under
semi-static test conditions. The test item solutions were prepared by
stirring an excess (100mg/L) of test item in test water using a
propeller stirrer at approximately 1500 rpm for24hours. After the
stirring period any undissolved test item was removed by filtration (0.2
µm Gelman Acrocap filter, first approximate 500 mL discarded in order to
pre-condition the filter) to produce a
100% v/v saturated solution of the test item. This saturated solution
was then further diluted as necessary, to provide the required test
concentrations. Immobilization and any adverse reactions to exposure
were recorded after 24 and 48 hours.
Analysis of the freshly prepared test media at 0 and 24 hours showed measured test concentrations to range from 3.9 to 64 mg/L. A decline in measured test concentration was observed in the old or expired test media at 24 and 48 hours to between 2.0 and 50 mg/L and hence it was considered appropriate to calculate the results based on the time-weighted mean measured test concentration only in order to give a “worst case” analysis of the data.
.
Analysis of the immobilization data by the maximum-likelihood probit method at 24 hours and trimmed Spearman-Karber method (Hamilton et al, 1977) at 48 hours based on the time-weighted mean measured test concentrations gave the following results:
The 24 h EC50 was 12 mg/L with 95 % confidence limits of 9.9 - 14 mg/L.
The 48 h EC50 was 11 mg/L with 95 % confidence limits of 9.2 - 12 mg/L.
The No Observed Effect Concentration after 24 and 48 hours exposure was 4.6 mg/L. The Lowest Observed Effect Concentration after 24 and 48 hours exposure was 8.7 mg/L.
The slopes and their standard errors of the response curves at 24 hours were 8.6 (SE = 1.7). Due to the nature of the data it was not possible to calculate the slope and error of response curve at 48 hours.
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