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EC number: 205-047-2 | CAS number: 132-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation
Data available for the structurally similar read across chemicals has been reviewed to determine the dermal irritation potential of the test chemical. Based on the summarized studies for target chemical and its structurally similar read across substances,it can be concluded that the testchemical is unable to cause skin irritation and considered as not irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified””.
Eye irritation
Data available for the structurally similar read across chemicals has been reviewed to determine the ocular irritation potential of the test chemical. Based on the summarized studies for target chemical and its structurally similar read across substances,it can be concluded that the testchemical is able to cause ocular irritation and considered as not irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Weight of evidence approach based on various test chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The skin irritation potential of test chemical was assessed on the basis of various summarized studies which were conducted on rabbits and represented as study 1, 2 and 3 for WoE-2,WoE-3 and WoE-4 respectively.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- other:
- Controls:
- not specified
- Amount / concentration applied:
- 1. 500 mg moistened with physiological saline
2. 100 mg
3. 500mg - Duration of treatment / exposure:
- 1. 24 hours
2,3. no data available - Observation period:
- 1. 24 and 72 hours
2,3. no data available - Number of animals:
- 1. 6(3/sex)
2,3. no data available - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
no signs of irritation observed- Interpretation of results:
- other: not irritating.
- Conclusions:
- Based on the result obtained from the summarized studies available for the structurally read across chemical, it can be estimated that the test chemical is unable to cause skin irritation and thus can be considered as not irritating.
- Executive summary:
The skin irritation potential of test chemical was estimated on the basis of various summarized studies available for the structurally read across chemicals which were conducted on rabbits. These studies have been summarized as below;
Study 1:
Draize test was performed to determine the primary dermal irritation potential of the test chemical in rabbits. 500 mg portion of the test article, moistened with physiological saline, was applied to shaved intact and abraded skin sites (under occlusive wrapping) of 6 New Zealand white albino rabbits (3M, 3F). At the end of 24 hrs, the test material was removed. The skin test sites were scored for erythema and edema according to Draize method at 24 and 72 hrs. No erythema or edema was observed on the intact and abraded skin sites. The overall Draize score was 0.0/8.0. Hence, the test chemical was considered to be not irritating to skin.
Study 2:
The skin irritation study was carried out on rabbits to determine the irritation potency of the test chemical. The rabbits were treated with 100mg undiluted test chemical and observed for effects. The test chemical did not produce any local reactions on the treated sites of the test animals. Hence the test chemical was considered to be non-irritant on rabbits’ skin.
Study 3:
The skin irritation study of the test chemical was carried out in rabbits to determine its irritation potency. 500mg of test material was applied on the intact and abraded skin of rabbits under occlusion. No known skin irritation effects were observed. Hence the test chemical was considered to be non-irritant on rabbits’ skin.
The aim of the above summarized studies was to investigate the possibility of causing dermal irritation by the test chemical. These studies were performed for the structurally similar read across chemical on rabbits by using different test methods. Overall, the results indicate that there is no strong evidence from which we can conclude that the chemical can be a potential skin irritant. Thusby applying the weight of evidence approachan interpretation can be drawn from these studies, that the chemical is not able to cause skin irritation and hence can be considered as not irritating to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The ocular irritation potential of test chemical was assessed on the basis of various summarized studies which were conducted on rabbits and represented as study 1 and 2 for WoE-2 and WoE-3 respectively.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 1. Viscoblau BG Teig
2. 100 mg - Duration of treatment / exposure:
- no data available
- Observation period (in vivo):
- no data available
- Number of animals or in vitro replicates:
- 1. 6
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of irritation observed
- Interpretation of results:
- other: not irritating
- Conclusions:
- Based on the result obtained from the summarized studies available for the structurally read across chemical, it can be estimated that the test chemical is unable to cause ocular irritation and thus can be considered as not irritating.
- Executive summary:
The ocular irritation potential of test chemical was assessed on the basis of various summarized studies available for the structurally read across chemicals which were conducted on rabbits. These studies have been summarized as below;
Study 1:
Eye irritation test was carried to estimate the irritation parameter of the test chemical. The dye was applied as Viscoblau BG Teig in 6 rabbits. Dulling of the cornea and mild conjunctival irritation were observed in 3 of 6 rabbits, but the total score resulted in classification under non- irritant. Therefore, the test chemical was considered to be a non-irritant under the test conditions.
Study 2:
The eye irritation potential of the test chemical was assessed in rabbits. 100 mg undiluted test chemical was instilled into the eyes of rabbits and observed for effects. 100 mg of the test chemical did not trigger any irritation on the rabbit eyes. Hence, the test chemical can be considered to be not irritating to eyes
The aim of the above summarized studies was to investigate the possibility of causing ocular effects by the test chemical. These studies were performed for the structurally similar read across chemical on rabbits by using different test methods. Overall, the results indicate that there is no strong evidence from which we can conclude that the chemical can be a potential ocular irritant. Thusby applying the weight of evidence approachan interpretation can be drawn from these studies, that the chemical is not able to cause eye damage and hence can be considered as not irritating to the eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The skin irritation potential of test chemical was estimated on the basis of various summarized studies available for the structurally read across chemicals which were conducted on rabbits. These studies have been summarized as below;
Study 1:
Draize test was performed to determine the primary dermal irritation potential of the test chemical in rabbits. 500 mg portion of the test article, moistened with physiological saline, was applied to shaved intact and abraded skin sites (under occlusive wrapping) of 6 New Zealand white albino rabbits (3M, 3F). At the end of 24 hrs, the test material was removed. The skin test sites were scored for erythema and edema according to Draize method at 24 and 72 hrs. No erythema or edema was observed on the intact and abraded skin sites. The overall Draize score was 0.0/8.0. Hence, the test chemical was considered to be not irritating to skin.
Study 2:
The skin irritation study was carried out on rabbits to determine the irritation potency of the test chemical. The rabbits were treated with 100mg undiluted test chemical and observed for effects. The test chemical did not produce any local reactions on the treated sites of the test animals. Hence the test chemical was considered to be non-irritant on rabbits’ skin.
Study 3:
The skin irritation study of the test chemical was carried out in rabbits to determine its irritation potency. 500mg of test material was applied on the intact and abraded skin of rabbits under occlusion. No known skin irritation effects were observed. Hence the test chemical was considered to be non-irritant on rabbits’ skin.
The aim of the above summarized studies was to investigate the possibility of causing dermal irritation by the test chemical. These studies were performed for the structurally similar read across chemical on rabbits by using different test methods. Overall, the results indicate that there is no strong evidence from which we can conclude that the chemical can be a potential skin irritant. Thusby applying the weight of evidence approachan interpretation can be drawn from these studies, that the chemical is not able to cause skin irritation and hence can be considered as not irritating to the skin.
Eye irritation
The ocular irritation potential of test chemical was assessed on the basis of various summarized studies available for the structurally read across chemicals which were conducted on rabbits. These studies have been summarized as below;
Study 1:
Eye irritation test was carried to estimate the irritation parameter of the test chemical. The dye was applied as Viscoblau BG Teig in 6 rabbits. Dulling of the cornea and mild conjunctival irritation were observed in 3 of 6 rabbits, but the total score resulted in classification under non- irritant. Therefore, the test chemical was considered to be a non-irritant under the test conditions.
Study 2:
The eye irritation potential of the test chemical was assessed in rabbits. 100 mg undiluted test chemical was instilled into the eyes of rabbits and observed for effects. 100 mg of the test chemical did not trigger any irritation on the rabbit eyes. Hence, the test chemical can be considered to be not irritating to eyes
The aim of the above summarized studies was to investigate the possibility of causing ocular effects by the test chemical. These studies were performed for the structurally similar read across chemical on rabbits by using different test methods. Overall, the results indicate that there is no strong evidence from which we can conclude that the chemical can be a potential ocular irritant. Thusby applying the weight of evidence approachan interpretation can be drawn from these studies, that the chemical is not able to cause eye damage and hence can be considered as not irritating to the eyes.
Justification for classification or non-classification
The skin and eye irritation potential of test chemical and its structurally similar read across substanceswere observed in various studies. The results obtained from these studies indicate that the chemical is unable to cause skin irritation and eye damage. Hence the test chemical can be classified under the category “Not Classified” for skin and eye as per CLP.
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