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Diss Factsheets
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EC number: 930-964-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- From 01.03.1979 to 29.05.1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Internal guideline used, valid at the time of study. No GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Internal guideline used, valid at the time of study.
The acute subcutaneous toxicity of monochloroacetic acid was studied on female Wistar rats. The doses tested were 80, 100, 125, 200 and 315 mg/kg bw (10 female rats per dose level). - GLP compliance:
- no
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Monochloressigsäure
- Physical state: white crystalline flakes
- Analytical purity: released by quality control
- Lot/batch No.: VA 2308
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Raised by Hoechst AG, own breeding.
- Weight at study initiation: 122-188 g; mean: 160 ± 19 g; n=50.
- Housing: Animals were housed in groups in plastic cages on wood shavings.
- Diet (e.g. ad libitum): Altromin 1324 (Altromin GmbH, Lage / Lippe), ad libitum.
- Water (e.g. ad libitum): Tap water, ad libitum.
IN-LIFE DATES: From: 01.03.1979 to 29.05.1979
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- physiological saline
- Details on exposure:
- 50% solutions in 0.9% saline (50 g MCA/ 100 mL saline.
It was given a single injection under the neck skin with different volumes (different doses). - Doses:
- 80, 100, 125, 200 and 315 mg/kg bw
- No. of animals per sex per dose:
- 10 female rats per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Within the observation period, animals were weighed weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Toxicity symptoms, mortality rate and time of death were recorded. - Statistics:
- LD50 calculation was based on probit analysis. Method acc. to Linder & Weber; confidence limits acc to Cavalli-Sforza.
Calculation program by Hoechst AG, department for Practical Mathematics.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 97.4 mg/kg bw
- 95% CL:
- 89.9 - 105.5
Any other information on results incl. tables
Table 07.02.04_01. Mortality rate.
Dose (mg/kg bw) | Concentration % | Number of dead animals / animals used |
80 | 50 | 1/10 |
100 | 50 | 5/10 |
125 | 50 | 10/10 |
200 | 50 | 10/10 |
315 | 50 | 10/10 |
Applicant's summary and conclusion
- Conclusions:
- A LD 50 of 97.4 mg/kg bw (89.9 - 105.5 mg/kg bw) was determined by Probit analysis.
- Executive summary:
- The acute subcutaneous toxicity of monochloroacetic acid was studied on female Wistar rats. The doses tested were 80, 100, 125, 200 and 315 mg/kg bw (10 female rats per dose level).
At the end of an observation period of 14 days, it was determined an LD 50 of 97.4 mg/kg bw (89.9 - 105.5 mg/kg bw) by Probit analysis.
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