Registration Dossier
Registration Dossier
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EC number: 204-982-3 | CAS number: 130-23-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- TOXICOLOGICAL EVALUATION of 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid
- Author:
- BG Chemie
- Year:
- 2 000
- Bibliographic source:
- BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Evaluate of eye irritation effect of 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid in rabbit.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 202-000-8
- EC Name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 90-51-7
- Molecular formula:
- C10H9NO4S
- IUPAC Name:
- 6-amino-4-hydroxynaphthalene-2-sulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid
- Molecular formula (if other than submission substance): C10-H9-N-O4-S
- Molecular weight (if other than submission substance): 239.25g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 50 mg
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: Slight reddening
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid is considered to be not irritant to rabbit eye.
- Executive summary:
Eye irritation test of 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid was conducted in rabbit. 50 mg of test chemical was instilled into theconjunctival sac of 2 rabbits. One hour after application, there was slight reddening observed, which are cleared up completely after 3 days Hence, the substance 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid is considered to be not irritant to rabbit eye
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