Registration Dossier
Registration Dossier
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EC number: 222-813-1 | CAS number: 3618-72-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Not conducted under GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 1.63
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not available
- Details on results:
- Concentrations of the n-octanol phase were calculated directly from the absorbance values.
Concentration of the double distilled water phase was very low: even applying direct measurement to this phase, absorbance values were far below the lower limit of the spectrophotometer’s sensibility. Measured differences were below the error limits of the method. - Conclusions:
- The n-octanol-water partition coefficient was performed according to OECD 107, Shake Flask Method. Under the experimental conditions the log Kow was determined to be 1.63 at 20°C.
- Executive summary:
The n-octanol-water partition coefficient was performed according to OECD 107, Shake Flask Method. Under the experimental conditions the log Kow was determined to be 1.63 at 20°C (Reach&Colours, 2015).
Reference
Description of key information
The partition coefficient was determined according to OECD Guideline107 (Reach&Colours, 2015) and by measurement of the respective concentrations in an octanol / water-containing system (HPV, 2002)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.63
- at the temperature of:
- 20 °C
Additional information
The higher and more conservative log Kow of 4.4 was chosen to represent the test substance.
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