Registration Dossier
Registration Dossier
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EC number: 203-562-7 | CAS number: 108-22-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitization potential of Isopropenyl acetate was assessed in 10 male and female Pirbright White Hsd/Win:DH guinea pigs using the Magnusson and Kligman maximization test in accordance with OECD Guideline 406. Intradermal induction was accomplished with a 5% dilution of the test item in water and Freund’s complete adjuvans. A week after the intradermal induction, the skin was pretreated with 10% sodium lauryl sulphate in petrolatum in order to cause mild irritation 24 hours prior to dermal induction by means of a 48 hour occlusive application of the undiluted test compound. Dermal challenge with undiluted test item through 24 h occlusive application, carried out two weeks after the second induction treatment, elicited no positive skin reactions in any of the guinea pigs treated. Therefore Isopropenyl acetate did not cause skin sensitizing effects under the conditions of this test.
Migrated from Short description of key information:
Isopropenyl acetate did not cause skin sensitizing effects under the conditions of this test.
Justification for classification or non-classification
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