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Diss Factsheets
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EC number: 252-354-2 | CAS number: 35086-59-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14. bis zum 28.02.1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in GLP compliance and is well documented, but no internationally acknowledged guidelines is mentioned.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: study protokoll
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3,5-Diacetoxyacetophenon
- IUPAC Name:
- 3,5-Diacetoxyacetophenon
- Details on test material:
- 96, in der A Qualitätskontrolle der Fa. Boehringer Ingelheim KG, analysiert und mit dem Analysenattest vom 10.01.1984 als "geeignet" freigegeben.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Chbb:THOM (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. K. Thomae Biberach/Riß
- Age at study initiation: males: 63 Tage, females: 77 Tage
- Weight at study initiation: males: 271,7 g, females 195,8 g Mittelwert
- Fasting period before study: 16 - 20 Std vor Applikation und 2 Std. nach Applikation
- Housing: Einzelhaltung der Tiere in Makrolonkäfigen Typ III mit Weichholzgranulateinstreu
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 21 Tage
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24°C + 2
- Humidity (%): c a . 55 % (min. 50 %, max. 65 %)
- Photoperiod (hrs dark / hrs light): 12 h / 12 h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Tylose
- Details on oral exposure:
- Applikationsvolumen: 10 ml/kg Körpergewicht
Konz. der Lösung. 50 g/100 ml - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Die Tiere wurden am 1. Versuchstag während der gesamten Arbeitszeit beobachtet.
Anschließend wurden sie bis zum 14. Versuchstag an Arbeitstagen zweimal täglich (morgens und nachmittags), an Wochenenden einmal (morgens) beobachtet.
Die Verhaltensänderungen bzw. Vergiftungssymptome wurden in Gruppenprotokollen erfaßt.
Weighing: Alle Versuchstiere wurden einen Tag vor Versuchsbeginn (Tag des Nüchternsetzens)
und vor der Applikation gewogen. Die überlebenden Tiere wurden am 8. und 15. Versuchstag gewogen und die Körpergewichtszunahme/
Gruppe für jede Versuchswoche wurde berechnet
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- nein
- Clinical signs:
- Nach Applikation von 5000 mg/kg Körpergewicht wurden
keine Verhaltensänderungen oder Vergiftungssymptome
beobachtet - Body weight:
- Die Körpergewichtsentwicklung der Tiere wurde durch
die Substanzgabe nicht beeinflußt - Gross pathology:
- Während der 14-tägigen Nachbeobachtungszeit wurden
keine Todesfälle registriert und bei der Obduktion
der Tiere am Versuchsende wurden makroskopisch keine
Organ- oder Gewebeveränderungen festgestellt.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Da nach Verabreichung der Höchstdosis von 5000 mg/kg
(OECD-Limit test in OECD Guidelines for testing chemicals,
Nr. 401, 1981) keine Todesfälle registriert
wurden, kann die Substanz 3,5-Diacetoxyacetophenon als
untoxisch nach peroraler Gabe an Ratten angesehen
werden.
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