Registration Dossier
Registration Dossier
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EC number: 236-338-2 | CAS number: 13310-75-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- GLP compliance:
- no
- Remarks:
- ; study performed according to SOP in a laboratory that conforms to GLP, but report was not audited by the QAU.
Test material
- Reference substance name:
- 2-propylvaleronitrile
- EC Number:
- 236-338-2
- EC Name:
- 2-propylvaleronitrile
- Cas Number:
- 13310-75-3
- Molecular formula:
- C8H15N
- IUPAC Name:
- 2-propylpentanenitrile
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand hybrid, SPF
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the contralateral zone serving as control
- Amount / concentration applied:
- 500 mg/animal
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 5 h (1h after bandage removal), 24h, 48h, and 72h
- Number of animals:
- 3 males
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0.443
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- S2477 (Dipropylacetonitrile) was not irritant to the skin. It must not be classified.
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