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Diss Factsheets
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EC number: 233-597-3 | CAS number: 10258-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1976
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material: 2-methoxyethyl cyanoacetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Young
- Weight at study initiation: 200 -300 g
- Fasting period before study: 24 h
- Housing: Common cage
- Diet: Ad libitum
- Water: Ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000, 4000, 5000, 6300, 8000, 16000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female animals per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: No
- Other examinations performed: Clinical signs, body weight, organ weights, histopathology, other: None - Statistics:
- No data.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 100 - 5 500
- Sex:
- male
- Dose descriptor:
- LD100
- Effect level:
- 6 300 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 900 - 4 700
- Sex:
- female
- Dose descriptor:
- LD100
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- See table 1 and 2 below for details.
- Clinical signs:
- other: Male and female animals dosed at 2000 mg/kg bw and 4000 mg/kg bw were languid with unkempt coats. At the 5000 mg/kg bw dosage level, the animals were sluggish with ruffled unkempt coats after dosing. Commencing on the second day unsteady and staggering ga
- Gross pathology:
- No data.
- Other findings:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study groups of fasted young albino rats (5 male/5 female per dose group) were given a single oral dose (gavage) of 2000, 4000, 5000, 6300, 8000, 16000 mg/kg bw and observed daily for 14 days. The obtained oral LD50 for males was 4700 mg/kg bw (95% C.I. 4100 – 550 mg/kg bw) and females was 4300 mg/kg bw (95% C.I. 3900 – 4700 mg/kg bw). The LD0 obtained for males and females was 2000 mg/kg bw. The LD100 for males was 6300 mg/kg bw and for females 5000 mg/kg bw. The test item was considered practically non-toxic.
- Executive summary:
A study similar or equivalent to EU Method B.1 and OECD Guideline 401 (Acute toxicity oral) was carried out. Groups of fasted young albino rats (5 male/5 female per dose group) were given a single oral dose (gavage) of 2000, 4000, 5000, 6300, 8000, 16000 mg/kg bw and observed daily for 14 days. The obtained oral LD50 for males was 4700 mg/kg bw (95% C.I. 4100 – 550 mg/kg bw) and females was 4300 mg/kg bw (95% C.I. 3900 – 4700 mg/kg bw). The LD0 obtained for males and females was 2000 mg/kg bw. The LD100 for males was 6300 mg/kg bw and for females 5000 mg/kg bw. The test item was considered practically non-toxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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