Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: well performed OECD study with GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxy-1-naphthaldehyde
EC Number:
211-902-0
EC Name:
2-hydroxy-1-naphthaldehyde
Cas Number:
708-06-5
Molecular formula:
C11H8O2
IUPAC Name:
2-hydroxynaphthalene-1-carbaldehyde
Details on test material:
Purity: 94%

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Hoechst AG, Kastengrund, conventional breeding
- Weight at study initiation: 2.3 - 2.5 kg
- Housing: in completely air conditioned rooms in single cages
- Diet: Altromin 2123 Haltungsdiat - Kaninchen ( ad libitum)
- Water: deionized and chlorinated water from automatic suspensors (ad libitum):


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+-3
- Humidity (%):50+-20
- Photoperiod: 12 hours daily

Test system

Vehicle:
other: Polyethyleneglycol 400
Controls:
other: the untreated right eye was the control
Amount / concentration applied:
100 mg test item suspended in 0.05 ml Polyethyleneglycol 400
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
3
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing:saline

SCORING SYSTEM:
cornea: 0 - 3
iris: 0- 2
conjunctivae: 0 - 3
chemosis: 0 - 4

TOOL USED TO ASSESS SCORE: UV lamp / fluorescein

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24 h
Score:
1
Max. score:
2
Reversibility:
fully reversible within: 72 h
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 72 h
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1 h
Score:
1.33
Max. score:
3
Reversibility:
fully reversible within: 7 days
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 7 days
Score:
0
Max. score:
3
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 1 h
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 7 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 7 days
Score:
0
Max. score:
4

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is not irritating to the eyes.
Executive summary:

The substance was tested for eye irritation according to OECD guideline 405. 3 albino Newzealand rabbits were administered 100 mg of the test item suspended in 0.05 ml Polyethyleneglycol 400 in the conjunctivae sac of the left eye. The observation period was 7 days.

Initial findings were fully reversible after 7 days. Therefore there is no need to classify the substance as irritant to the eye.