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Diss Factsheets
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EC number: 484-460-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short term fish
One short-term toxicity test on fish, performed according to the OECD Guideline 203, with MPKO, the major hydrolysis product of OS1600, is available. In this study the toxicity of MPKO to Rainbow trout (Oncorhynchus mykiss) was evaluated with a limit test during a 96h, static exposure. Fish were exposed to either the control medium or 100 mg/L MPKO (nominal concentration) or 103 mg/L MPKO (measured concentration at the end of exposure). Overall, no mortalities or other significant adverse affects were observed in any of the fish exposed to 100 mg/L MPKO for 96 hrs.
In conclusion, the 96h LC50 value for rainbow trout for MPKO was > 100 mg/L while the NOEC or “no observed effect concentration” was 100 mg/L and the LOEC was >100 mg/L. Therefore, It can be concluded that the substance is not acutely toxic for fish.
Short term invertebrates
One short-term toxicity test on aquatic invertebrates, performed according to OECD Guideline 202, with MPKO, the major hydrolysis product of OS1600, is available. In this study, the toxicity of MPKO toDaphnia magnawas evaluated with a limit test during 48 hour, static exposure.Daphniawere exposed to either a control medium or 100 mg/L MPKO (nominal concentration). The results on cumulative immobilisation indicated that 5% immobilization occurred in the dilution water control at 48 hours and that no immobilisation occurred in the test concentration at 48 hours. The 48h EC50 (immobilisation) value for MPKO withDaphnia magnawas determined to be >100 mg/L MPKO, while theNOECor “no observed effect concentration” was >= 100 mg/L. Therefore, it can be concluded that the substance is not acutely toxic for invertebrates.
Short term algae
One study on the freshwater alga (Pseudokirchneriella subcapitata), performed according to the OECD Guideline 201 is available. This study evaluated the toxicity of MPKO during a 72h exposure. Algae were exposed to a control medium and a medium containing 5.6, 10, 18, 32, 56, and 100 mg/L MPKO (nominal). The EbC50 (biomass) was 50 mg/L MPKO and the ErC50 (growth rate) was 88 mg/L MPKO. The NOEC for both biomass and growth rate was 32 mg/L MPKO.
Toxicity to microorganisms
Microbial toxicity of OS1600 was derived from an available ready biodegradation test, performed according to OECD guideline 301B. In this test, ready biodegradability was tested by monitoring CO2 evolution. Both a positive control and a toxicity control were included in the test setup. In the toxicity control OS1600 was added at a concentration of 21.5 mg/L. Validity criteria of the test were fulfilled. Since in the toxicity control more than 25% degradation occurred within 14 days (32 % based on ThCO2) it can be considered that the test substance does not inhibit microbial activity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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