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EC number: 200-193-3 | CAS number: 54-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-10-08 to 2014-10-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with standard test protocols (OECD 104 resp. EU A.4) in a quality controlled laboratory. The study is valid according to criteria mentioned in the test protocols.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: by loss of weight or by trapping vaporisate
- Remarks:
- weight loss
- Temp.:
- 20 °C
- Vapour pressure:
- 5.81 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 8.83 Pa
- Transition / decomposition:
- no
- Conclusions:
- The vapour pressure of the test item nicotine was determined at three different temperatures (30 °C, 40 °C, and 50 °C) according to EU method A.4 (effusion method; weight loss).
All experiments showed good reproducibility, giving relative standard deviations of less than 17 % and good correlation. Therefore, the result of the test can be considered valid. - Executive summary:
The vapour pressure of nicotine was determined according to EU method A.4 (effusion method; weight loss).
The vapour pressure was examined at three different temperatures (30 °C, 40 °C, and 50 °C). The common logarithm of the measured vapour pressure (log p) was plotted against 1/T. The data were fitted by linear regression with a correlation coefficient of -0.9994.
For the test item nicotine, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 5.81Pa
Vapour pressure at 25 °C: 8.83Pa
Reference
The vapour pressure of nicotine was determined through weight loss in an effusion cell according to Knudsen. The measurement was performed at 30 °C, 40 °C, and 50 °C.
T [°C] |
T [K] |
p [Pa] |
Standard deviation p [Pa] |
Relative standard deviation p [%] |
30.0 |
303.2 |
13.1 |
0.39 |
3.0 |
40.0 |
313.2 |
29.6 |
4.88 |
16.5 |
50.0 |
323.2 |
58.1 |
3.58 |
6.2 |
The vapour pressure was calculated from
p = [m/(K·A·t)] · [(2·π·R·T)/M]1/2
with
p |
vapour pressure to be determined [Pa] |
m |
weight loss [kg] |
t |
time [s] |
A |
area of aperture = 1.96 · 10-7m2 |
K |
correction factor = 0.834 |
R |
8.3144 J/(mol·K) |
T |
temperature [K] |
M |
molecular weight of test item = 0.1622 kg/mol |
To determine the vapour pressure of nicotine at 20 °C and 25 °C, the common logarithm of the measured vapour pressure (log p) was plotted against 1/T. The data were fitted by linear regression:
y = -3174.3 · x + 11.593; r = -0.9994; r2= 0.9987
with
y |
log p; [p] = Pa |
x |
1/T; [T] = K |
r |
correlation coefficient |
r2 |
coefficient of determination |
From the regression equation, the following vapour pressures were calculated:
Vapour pressure at 20 °C: 5.81 Pa
Vapour pressure at 25 °C: 8.83 Pa
Description of key information
Study was conducted in a quality controlled laboratory. The results are reliable without restriction. Key study is appropriate for the risk assessment.
Key value for chemical safety assessment
- Vapour pressure:
- 5.81 Pa
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.