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EC number: 234-042-8 | CAS number: 10508-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
key studies, OECD Guideline 111, GLP, validity 2:
- Half-life (pH 4; 50°C) = 2310.5 hours;
- Half-life (pH 7; 50°C)= 1386.3 hours;
- Half-life (pH 9; 50°C) = 990.2 hours.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 386.3 h
- at the temperature of:
- 50 °C
Additional information
Two valid key studies are available to assess the hydrolysis potential of di-tert-amyl peroxide as a function of pH. These studies were performed according to the OECD Guideline 111 with GLP statement.
The same preliminary test was performed for the two studies. In this preliminary test, the test substance was added into each buffer (pH 1.2, 4, 7 and 9; de-oxygenated by bubbling nitrogen) as follow: 15 µL of test item were mixed with 750mL of each buffer during one night under stirring. The solutions were then separated by decantation and 250 mL of clear solution were diluted to 500 mL with the corresponding buffers. These solutions were transferred to 100 mL flasks, closed with butyl rubber caps. Two replicates were prepared for each buffer. All test vessels were incubated at 50 +/- 0.5 °C and kept protected from light during five days. The solutions were then analysed. The results showed a decrease of the test substance with all buffers. One can conclude that the results obtained in the preliminary test did not demonstrate actual hydrolysis but might reveal a loss of the test item due to its volatility.
The definitive tests were performed at pH 7 and 9 (corresponding to the first key study) and at pH 4 (corresponding to the second key study).
The test substance was added into each buffer (pH 4, 7 and 9; de-oxygenated by bubbling nitrogen) as follow: 20 µL (for pH 7 and 9) of 40 µL (for pH 4) of test item were mixed with 1 L (for pH 7 and 9) or 2L (for pH 4) of buffer during 30 min under stirring (Slow Stir flasks). The solutions were then separated by decantation and the convenient volume of clear solutions were then used for the preparation of the series of flasks. Series of 36 mL flasks were then prepared and incubated at 50, 37 and 15°C. Two replicates were prepared for each buffer. The solutions were then analysed along with time.
At pH 7 and 50 °C, after 32 days, hydrolysis was only 46.2 %. For the other temperatures, 21.2 % of the test item were hydrolyzed in 32 days at 37 °C and 9.6 % in 32 days at 15 °C. Pseudo-first order reaction kinetics can only be observed at 50 °C. Therefore, it was not possible to calculate half-times at 37 and 15 °C. At pH 9 and 50 °C, after 32 days, hydrolysis was 62.8 %. For the other temperatures, 32 % of the test item were hydrolyzed in 32 days at 37 °C and 14.1 % in 32 days at 15 °C. Pseudo-first order reaction kinetics can only be observed at 50 °C.Therefore, it was not possible to calculate half-times at 37 and 15 °C. At pH 4 and 50 °C, after 24 days, hydrolysis was only 21.2 %. For the other temperatures, 15 % of the test item were hydrolyzed in 24 days at 37 °C and no hydrolysis was clearly observed after 30 days at 15 °C. Pseudo-first order reaction kinetics can only be observed at 50 °C. Therefore, it was not possible to calculate half-times at 37 and 15 °C.
In conclusion, significant hydrolysis of the test substance is not observed. This substance is thus considered as stable.
The half-life time at 25°C cannot be extrapolated from the results obtained at the 3 temperatures tested, for each pH, using Arrhenius equation.
The half-life times for the test substance as a function of pH are presented below:
- Half-life (pH 4; 50°C) = 2310.5 hours;
- Half-life (pH 7; 50°C)= 1386.3 hours;
- Half-life (pH 9; 50°C) = 990.2 hours.
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