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Diss Factsheets
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EC number: 436-060-3 | CAS number: - FC 84508 PK
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Oct. 26, 2000 to Nov. 27, 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Secondary effluent of a domestic sewage treatment plant (KIäranlage Odenthal)
- Preparation of inoculum for exposure: Separation of coarse particles by filtration
- Pretreatment: Aeration of mineral medium plus inoculum (filtrate) for 6 d
- Concentration of effluent in reaction mixture: 5 mL/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 3.7 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral medium
TEST SYSTEM
- Culturing apparatus: Bottles
- Number of culture flasks/concentration: 10 bottles
- Test performed in closed vessels due to significant volatility of test substance: Yes
- Test performed in open system: No
SAMPLING
- Sampling frequency: 7, 14, 21 and 28 d
- Sampling method: Degradation is followed by analysis of dissolved oxygen over a 28 d period. The amount of oxygen taken up by the microbial population during biodegradation of the test substance, corrected for uptake by the blank inoculum run in parallel, is expressed as a percentage of ThOD or COD.
CONTROL AND BLANK SYSTEM
- Inoculum blank: A measured volume of mineral medium containing only inoculum
- Procedure control: The reference chemical sodium benzoate is tested by setting up 2 flasks in parallel to the normal tests runs
- Toxicity control: containing test substance, reference substance and inoculum - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 2.9 mg/L
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 14 d
- Details on results:
- Theoretical oxygen demand: 1899 mg O2/g
- Results with reference substance:
- The reference substance showed 78 % degradation after 14 and 28 d.
Theoretical oxygen demand: 1665 mg O2/g - Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Under the test conditions, the test substance is not readily biodegradable.
- Executive summary:
A study was performed to assess the ready biodegradability of test substance according to EU Method C.4-E. and OECD Guideline 301 D in compliance with GLP.
The test substance in a mineral medium was inoculated with secondary effluent and incubated for 28 d under aerobic conditions in completely full, closed bottles. During this period the biodegradation is followed by analysis of dissolved oxygen. The amount of oxygen taken up by the test chemical, corrected for uptake by the blank inoculum run in parallel, is expressed as a percentage of theoretical oxygen demand (ThOD) or chemical oxygen demand (COD).
The test substance showed 0 % degradation after 7, 14, 21, 28 d. Therefore, the test substance is classified as not readily biodegradable. The reference substance showed 78 % degradation after 14 d.
Under the test conditions, the test substance is classified as not readily biodegradable.
Reference
Toxicity control: Showed 32 % of degradation after 14 and 28 d.
The used concentrations of the test substance did not show toxic effects to bacteria.
Description of key information
The test substance is not readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
A study was performed to assess the ready biodegradability of test substance according to EU Method C.4-E. and OECD Guideline 301 D.
The test substance in a mineral medium was inoculated with secondary effluent and incubated for 28 d under aerobic conditions in completely full, closed bottles. During this period the biodegradation is followed by analysis of dissolved oxygen. The amount of oxygen taken up by the test chemical, corrected for uptake by the blank inoculum run in parallel, is expressed as a percentage of theoretical oxygen demand (ThOD) or chemical oxygen demand (COD).
The test substance showed 0 % degradation after 7, 14, 21, 28 d. Therefore, the test substance is classified as not readily biodegradable. The reference substance showed 78 % degradation after 14 d. The test substance is classified as not readily biodegradable (Dr. Muller, 2000).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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