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EC number: 231-915-5 | CAS number: 7778-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 500 mg/kg bw/day
Additional information
An OECD 422 study with rats shows no effects at all up to doses of 1500 mg/kg bw/day of potassium sulphate. No effects were found on reproduction parameters, neither embryotoxic or developmental effects were seen. No further studies with potassium sulphate were present.
In a 90 -day repeate dose toxicity study with ammonium sulfate no histological changes of testes were observed up to 1792 mg/kg bw/day. The ovaries were not examined.
In a one-generation study in female mice, sodium sulphate was given in drinking water at levels up to 5000 mg/L (ca. 1790 -6560 mg/kg bw/day), beginning one week prior to breeding and up to 14 days during lactation. No differences were found in litter size, litter weaning weights or gestational or lactational weight gain of the dams among sulphate treatements. No toxicity to the dams was found. Litters were not examined histopathologically and fertility indices were not measured. Only females were treated.
No further studies are considered necessary. Potassium sulphate dissociates into K+ and sulphate ions. Sulphate is a normal body and nutritional component and is regulated within the body. K+ is also a necessary element of which the ADI is 2000 -4000 mg/day (Dutch Voedingscentrum). Together with the available data showing no effects, an additional 2 -generation reproduction study is not considered necessary.
Short description of key information:
In a reliable OECD screening study in rats with potassium sulphate no effects were found up to the highest dose tested (1500 mg/kg bw/d). No further studies with potassium sulphate itself were present. However, in repeated dose studies with ammonium sulphate no effects on reproduction organs were found and in addition in a limited one-generation study where only females were treated no effects were found. In addition, potassium sulfate dissociates into K+ and sulfate ions which are nutritional components regulated within the body. The overall conclusion for potassium sulphate is that the substance may present a hazard to fertility but only at parentally toxic doses.
Effects on developmental toxicity
Description of key information
In a reliable OECD screening study in rats with potassium sulphate no effects were found up to the highest dose tested (1500 mg/kg bw/d). No further studies with potassium sulphate itself were present. However, in repeated dose studies with ammonium sulphate no effects on reproduction organs were found and in addition in a limited one-generation study where only females were treated no effects were found. In addition, potassium sulfate dissociates into K+ and sulfate ions which are nutritional components regulated within the body. The overall conclusion for potassium sulphate is that there is no evidence that the substance may present a risk for developmental toxicity.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 500 mg/kg bw/day
Additional information
An OECD 422 study with rats shows no effects at all up to doses of 1500 mg/kg bw/day of potassium sulphate. No effects were found on reproduction parameters, neither embryotoxic or developmental effects were seen. No further studies with potassium sulphate were present. With other sulphate compounds also no studies are available relating to developmental toxicity. No further studies with potassium sulphate itself were present. However, in repeated dose studies with ammonium sulphate no effects on reproduction organs were found and in addition in a limited one-generation study where only females were treated no effects were found.
No further studies are considered necessary. Potassium sulphate dissociates into K+ and sulphate ions. Sulphate is a normal body and nutritional component and is regulated within the body. K+ is also a necessary element of which the ADI is 2000 -4000 mg/day (Dutch Voedingscentrum). Together with the available data showing no effects, a developmental toxicity is not considered necessary.
Justification for classification or non-classification
The results of the OECD screening study (a very high NOAEL) and data with other sulphate compounds do indicate that no classification is required for potassium sulphate according to Directive 67/548/EC and the CLP directive.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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