Registration Dossier
Registration Dossier
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EC number: 700-374-1 | CAS number: 70918-00-2
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: quality controlled study, comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
- Principles of method if other than guideline:
- Dissolution test/flask method: Take 1 g of test sample in a dry 50 ml volumetric flask and dissolved it with n-Octanol and observe
the clarity of solution for complete dissolution. The volumes of n-Octanol used for complete dissolution were noted down
(calibrated glassware used).
9 tests were performed to solve 1 gram of substance in n-Octanol. - GLP compliance:
- yes (incl. QA statement)
- Remarks:
- ISO 9001
Test material
- Reference substance name:
- 2,3-Dihydro-1,4-benzodioxin-2-yl(piperazin-1-yl)methanone
- EC Number:
- 700-374-1
- Cas Number:
- 70918-00-2
- Molecular formula:
- C13H16N2O3
- IUPAC Name:
- 2,3-Dihydro-1,4-benzodioxin-2-yl(piperazin-1-yl)methanone
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubility
- Medium:
- n-octanol
- Solubility:
- 34.483 g/L
- Remarks on result:
- other: tests were done at room temperature; results are a mean of 9 independent measurements;
- Test substance stable:
- yes
- Details on results:
- 9 tests were performed to solve 1 gram of substance in n-Octanol. The mean quantity of n-Octanol used is 29 ml for 1 gram of substance.
Any other information on results incl. tables
9 tests were performed to solve 1 gram of substance in n-Octanol: mean = 29 ml.
The test were done at room temperature (not explicitly mentioned, oral communication).
Solubility is 34.4827 g/L.
Applicant's summary and conclusion
- Conclusions:
- The solubility of the substance in n-Octanol is 34.4827 g/l.
- Executive summary:
Solubility of 2,3-dihydro-1,4-benzodioxin-2-yl(piperazin-1-yl)methanone in n-Octanol: 34.4827 g/L.
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