Registration Dossier
Registration Dossier
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EC number: 203-090-1 | CAS number: 103-23-1
Endpoint summary
Administrative data
Description of key information
Additional information
One study investigating the toxicity to terrestrial organisms is available for Bis(2-ethylhexyl) adipate (CAS 103-23-1, DEHA). The study was performed according to EU method C.8 using Eisenia foetida as test organisms (Huels 1996). Different nominal concentrations between 100 and 1000 mg/kg d.w. were tested. Mortality was recorded after 7 and 14 days exposure time. Whereas no earthworm died in the control and test concentrations up to 500 mg/kg, 17 animals (out of 40) died in the 1000 mg/kg treatment. Thus, the 14d-LC0 is determined to be 500 mg/kg d.w. and the 14d-LC50 is determined to be 865 mg/kg d.w. based on nominal concentrations. Based on this result it can be concluded that DEHA is not toxic to terrestrial organisms at relevant environmental concentrations.
In accordance with Regulation (EC) No. 1907/2006, Annex X, Column 2, 9.4 further studies on the effects on terrestrial organisms does not have to be conducted since the chemical safety assessment indicates that there is no need. The test substance is readily biodegradable and will therefore not persist in soil for an extended period of time. Furthermore, the substance is not toxic to aquatic organisms up to the limit of water solubility and available data indicate that DEHA is not bioaccumulative. Due to its high adsorption potential DEHA is considered to be immobile in soil and uptake by roots via pore-water is not expected. Studies with aquatic microorganisms showed that DEHA is rapidly degraded and show no inhibitory effect. Hence, the risk the substance poses to terrestrial plants and microorganisms is considered to be low and a study is not considered to be necessary.
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