Registration Dossier
Registration Dossier
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EC number: 205-582-1 | CAS number: 143-07-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96h) = 5 mg/L (meas. geom. mean)
Key value for chemical safety assessment
Additional information
Four studies on the short-term toxicity of lauric acid to fish are available.
In the key GLP study (Ministry of the Environment of Japan, 2001) the toxicity to Oryzias latipes was tested under semi-static conditions according to OECD 203. After incubation time of 96 hours the LC50 was determined as 5 mg/L (meas. geom. mean).
Richterich and Mühlenberg (2001) summarised a non-GLP study conducted in 1981 according to ISO 7346-1 with Danio rerio under semi-static conditions. The resulting LC50 (96h) was 150 mg/L.
The publication by Onitsuka (1989) describes a 48 hours test with Oryzias latipes in freshwater and seawater and determined LC50s (48h) as >1000 mg/L in seawater and 8.6 mg/L in freshwater.
Geisel and Berger (1998) reported an LC50 (96h) of 150 mg/L in a test with Danio rerio. However, only a short abstract is available and was this rated reliability 4.
In conclusion, lauric acid shows toxic effects to fish at 5 mg/L, as this is the most sensitive reported LC50.
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