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EC number: 287-477-0 | CAS number: 85535-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited reporting, however study considered adequate for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of rats were given a single oral dose of a C14-17 chlorinated paraffin (chlorinated to either 40 or 45%) and observed for up to 14 days.
- GLP compliance:
- no
- Remarks:
- Prior to GLP
- Test type:
- other: acute oral LD50 study according to Company's Methods manual
- Limit test:
- yes
Test material
- Reference substance name:
- Alkanes, C14-17, chloro
- EC Number:
- 287-477-0
- EC Name:
- Alkanes, C14-17, chloro
- Cas Number:
- 85535-85-9
- Molecular formula:
- Substance is a range of chlorinated isomers of C14 to C17 paraffin
- IUPAC Name:
- Alkanes, C14-17, chloro
- Details on test material:
- - Name of test material (as cited in study report): Meflex DC024 and Meflex DC029
- Substance type: technical product
- Physical state: pale yellow liquid
- Impurities (identity and concentrations): 0.2% epoxy soya bean oil; 0.3% lubrizol LZ55A; 0.3% polyethylene glycol; 0.2% NonoxWSL
- Composition of test material, percentage of components: Meflex DC024; a C14-17 n-paraffin, chlorinated to 40%. Meflex DC029; a C14-17 n-paraffin, chlorinated to 45%
- Stability under test conditions: "good"
- Storage condition of test material: ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Alderley Park SPF colony- Weight at study initiation: 150-250 g- Fasting period before study: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- 10 ml/kg bw
- No. of animals per sex per dose:
- Groups of 6 animals (sex not specified)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: no data- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight,
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No confidence limits given
- Mortality:
- No deaths reported for Meflex DC024 or Meflex DC029
- Clinical signs:
- other: Restricted to incontinence during the first 48 hours, although numbers of animals affected and with which specific test material not reported.
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
No data was available on the effects of the individual materials on individual animals
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- No deaths or other severe adverse effects were seen in rats observed for 14 days following gavage administration of Meflex DC024 or Meflex DC029 (C14-17 chlorinated paraffins; 40 or 45% chlorination) as a single oral dose at 10 ml/kg bw . The oral LD50 is greater than 10 ml/kg bw.
- Executive summary:
Groups of six albino rats were given a single dose of C14-17 chlorinated paraffins (Meflex DC024, 40% chlorinated or Meflex DC029, 45% chlorinated) by stomach tube at a dose level of 10 ml/kg bw. Animals were observed for 14 days after dosing for abnormal clinical signs. No mortalities were observed for either of the tested chlorinated paraffins, and body weight gains over the observation period were reported as "normal". The acute oral LD50 for both C14-17 chlorinated paraffins is greater than 10 ml/kg bw and therefore neither test material would be classified for acute oral toxicity under EU CLP or DSD regulations.
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