Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-818-0 | CAS number: 126-99-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of chloroprene in an acute test during oral administration
- Author:
- Asmamgulian, T., A.; et al.
- Year:
- 1 971
- Bibliographic source:
- Proceedings of the Yerevan Medical Institute, vol. XV, 461-465
Materials and methods
- Principles of method if other than guideline:
- other: acute oral toxicity study
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
Test material
- Reference substance name:
- 2-chlorobuta-1,3-diene
- EC Number:
- 204-818-0
- EC Name:
- 2-chlorobuta-1,3-diene
- Cas Number:
- 126-99-8
- Molecular formula:
- C4H5Cl
- IUPAC Name:
- 2-chlorobuta-1,3-diene
- Details on test material:
- chloroprene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sunflower seed oil
- Doses:
- 150 to 400 mg/kg bw
- No. of animals per sex per dose:
- total number of rats used: 54
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 251 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: clinical signs, death, pathological changes in the inner organs and brain membrane
Any other information on results incl. tables
Clinical signs: symptoms of a depressed nervous system, animals were apathetic, death occured usually within the first day, survivors were comparable to the control at study termination
Autopsy of decedent: irregular blood content of the inner organs, hemorrhages foci in the brain membrane
Microscopic evaluations of decedents: blood vessels of the liver plethoric showed a turbid swelling, some lung alveoles were collapsed, lung tissue with formolic pigment, diapedesis of erythrocytes, epicardium was loosened up in spots, muscle fibers showed a turbid swelling, the fatty tissue of myocardium under epicardium and endocardium with foci of hemorrhages, the pulp of the spleen was plethoric with aggregated of eosinophiles, epithelium of the convoluted channels in the kidneys with distinct granular dystrophy, vessel of the brain cortex showed plethoric, the brain vessels were severely plethoric and had foci of hemorrhages, the brain tissue was swollen, stomach with a moderate leuco- and lymphocytic infiltration and a pronounced accumulation of eosinophiles
Applicant's summary and conclusion
- Executive summary:
Oral LD50 value in rats: 251 mg/kg bw; the clinical picture of acute poisoning is characterized by depression of the central nervous system. Patho-morphological changes in decedents after single oral application were mainly plethora, hemorrhages and dystropic changes in the central nervous system and in the inner organs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.