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EC number: 914-129-3 | CAS number: 12336-95-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Proprietary study, reported in summary form only but in sufficent detail to allow reliable interpretation of the adequacy of the method and results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study is not reported in great detail but appears to be broadly comparable to OECD 401; bodyweights were not measured and gross necropsy not performed.
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chromium hydroxide sulphate
- EC Number:
- 235-595-8
- EC Name:
- Chromium hydroxide sulphate
- Cas Number:
- 12336-95-7
- Molecular formula:
- CrHO5S
- IUPAC Name:
- chromium hydroxide sulphate
- Details on test material:
- The test material is referred to as 'Chromosal B'
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male Wistar rats (160-180 g) were obtained from Winkelmann (Germany) and were group housed (5 animals/cage)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- No further details
- Doses:
- 1000, 3100, 3500, 4000, 4500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- No further details
- Statistics:
- LD50 calculation according to the method of Fink & Hund (Arzneimittel-Forschung 15, 624; 1965)
Results and discussion
- Preliminary study:
- Not reported
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LDLo
- Effect level:
- 3 100 mg/kg bw
- Remarks on result:
- other: 1/10 rats
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 530 mg/kg bw
- 95% CL:
- 3 190 - 3 790
- Sex:
- male
- Dose descriptor:
- LD100
- Effect level:
- 5 000 mg/kg bw
- Mortality:
- Deaths occured at 3100 mg/kg bw (1), 3500 mg/kg bw (7), 4000 mg/kg bw (7), 4500 mg/kg bw (9) and 5000 mg/kg bw (10).
- Clinical signs:
- other: Signs of toxicity (emaciation, red staining of the eyes and nose, reduction in common parameters) were seen in all animals at dose levels of 3100 mg/kg bw and greater
- Gross pathology:
- Not reported
- Other findings:
- No other findings are detailed
Any other information on results incl. tables
The results of the study are tabulated below. The LD50 in male rats was found to be >3100 mg/kg bw and was calculated to be 3530 (3190 -3790) mg/kg bw.
Dose level (mg/kg bw) |
No. animals |
Signs of toxicity |
Deaths |
Time of death |
1000 |
10 |
- |
- |
- |
3100 |
10 |
10 |
1 |
3h |
3500 |
10 |
10 |
7 |
2-9d |
4000 |
10 |
10 |
7 |
2-5d |
4500 |
10 |
10 |
9 |
2-7d |
5000 |
10 |
10 |
10 |
2-4d |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the test material was calculated to be 3530 mg/kg bw. Classification for acute oral toxicity according to current EU criteria is not required.
- Executive summary:
In a study comparable to OECD Test Guideline 401 Wistar rats (10 males/group) were gavaged with a single dose of the test material (in water) at dose levels of 1000, 3100, 3500, 4000, 4500 or 5000 mg/kg bw and observed for 14 days. Deaths occurred at 3100 mg/kg bw (1), 3500 mg/kg bw (7), 4000 mg/kg bw (7), 4500 mg/kg bw (9) and 5000 mg/kg bw (10) within 9 days of exposure. Signs of toxicity (emaciation, red staining of the eyes and nose, reduction in common parameters) were observed at dose levels of 3100 mg/kg bw and above. The LD50 was calculated to be 3530 (3190 -3790) mg/kg bw.
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