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EC number: 271-678-5 | CAS number: 68603-87-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Animals were observed for 14 days
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Carboxylic acids, di-, C4-6
- EC Number:
- 271-678-5
- EC Name:
- Carboxylic acids, di-, C4-6
- Cas Number:
- 68603-87-2
- Molecular formula:
- C5H8O4, C4H6O4, C6H10O4
- IUPAC Name:
- Carboxylic acids, C4-6 di-
- Details on test material:
- Test Material: dibasic acid concentrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 6 dose level; 3160; 3980; 5010; 6310; 7940; 10000 mg/kg bw
- No. of animals per sex per dose:
- 2-3 males; 2-3 females; overall 5 animals per dose group
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 3 980 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 000 mg/kg bw
- 95% CL:
- >= 5 400 - <= 6 720
- Mortality:
- see Table 1
Any other information on results incl. tables
Signs of intoxication: weight loss (one day in survivors), increasing weakness, salvation, collapse and death.
Gross autopsy:
5010 and 6310 mg/kg group: Hemorrhagic lungs, liver, kidney and spleen discoloration and acute gastrointestinal inflamation.
7940 and 10000 mg/kg group: Lung and liver hyperemia
Survivors (day 14): Viscera appeared normal.
Table 1: mortalities
Dosage (mg/kg bw) | mortality males | mortality females | mortality combined |
3160 | 0/3 | 0/2 | 0/5 |
3980 | 0/2 | 0/3 | 0/5 |
5010 | 1/3 | 0/2 | 1/5 |
6310 | 0/2 | 3/3 | 3/5 |
7940 | 3/3 | 2/2 | 5/5 |
10000 | 2/2 | 3/3 | 5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
An oral LD50 value of 6000 mg/kg (95% confidence limits 5400 - 6720 mg/kg) was reported in rats in study similar to OECD TG 401 with doses up to 10000 mg/kg. In this study a 20% aqueous solution of a dicarboxylic acid mixture was tested and mortality was seen during the first 4 days; most deaths were reported within the first day. Signs of intoxication were weight loss (one day in survivors), increased weakness, salvation, collapse and death. Lethal doses caused hemorrhagic lungs, liver, kidney and spleen discoloration and acute gastrointestinal inflamation. Animals that survived to termination (day 14) appeared normal.
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