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Diss Factsheets
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EC number: 200-842-0 | CAS number: 75-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system. Not relevant to exposure (unphysiological pathway of application).
Data source
Reference
- Title:
- No information
- Author:
- BASF AG (1963). Department of Toxicology.|Gewerbetoxikologische Vorprüfung. Unpublished study results|(XIII/18), 26 March 1963.
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Formamide
- EC Number:
- 200-842-0
- EC Name:
- Formamide
- Cas Number:
- 75-12-7
- Molecular formula:
- CH3NO
- IUPAC Name:
- formamide
- Details on test material:
- TS-Freetext:
Formamide, degree of purity not reported.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Hannover
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- ca. 227, 1813, 2266, 2833, 3626, 7251 mg/kg bw (0.2, 1.6, 2.0, 2.5, 3.2, 6.4 ml/kg bw)
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 720 mg/kg bw
Any other information on results incl. tables
RS-Freetext:
Original values:
LD50 = 2.4 (2.06-2.8) ml/kg bw (related to the pure test
substance after 7 days; = 2720 (2334-3172) mg/kg bw
(calculated with a density of 1.133 g/cm3).
LD50 ca. 2.0 ml/kg bw (ca. 2266 mg/kg bw) related to the
pure test substance after 14 days.
No signs of toxicity and no deaths were observed at the
lowest dose level; these animals were sacrificed after an
observation period of 7 days (higher dose groups:
observation period of 14 days). In the other groups,
clinical signs were observed beginning on the day of dosing.
Clinical symptoms included dyspnea, ataxia, apathy,
imbalance, atony, lateral recumbent position and reduced
food consumption. The symptoms were observed immediately
after dosing (highest dose level) or at the day of dosing
(groups administered 1.6-3.2 ml/kg bw) and resolved slowly
within 11-12 days. Late deaths were observed; animals died
within 2 hours after dosing and up to 9 days after dosing.
All mice of the highest dose group were dead on the day
after dosing. Surviving rats appeared normal within 11-12
days after dosing. Autopsy revealed a fatty degeneration of
the liver in two of the animals that died. No other
pathological findings were reported.
dose level test deaths after
[ml/kg] [mg/kg] conc. 1 h 24 h 48 h 7 d 14 d
===========================================================
0.2 ca. 227 2% 0/10 0/10 0/10 0/10 --
1.6 ca. 1813 20% 0/10 0/10 0/10 1/10 3/10
2.0 ca. 2266 20% 0/10 0/10 0/10 3/10 3/10
2.5 ca. 2833 20% 0/10 0/10 1/10 1/10 1/10
3.2 ca. 3626 30% 0/10 0/10 1/10 9/10 9/10
6.4 ca. 7251 30% 0/10 10/10 10/10 10/10 10/10
===========================================================
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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