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EC number: 402-130-7 | CAS number: 106246-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Details on sampling:
- No analytics performed
- Vehicle:
- yes
- Details on test solutions:
- The test substance was dissolved in an auxiliary solvent, 10% Tween 80-dimethylformamide, to give a preliminary stock solution of 100 mg/ml. An aliquot (50 ul) of this stock solution was added to each of the test replicate beakers giving a final test concentration of 10 mg/l. Solvent controls were prepared in the same manner using solvent only.
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- A mixed population of activated sewage sludge micro-organisms was used as inoculum. The sample was collected from a predominantly domestic sewag treatment plant close to the test lab on 5 June 1996. The sample was maintained at 20 +/- 2°C with continuous aeration and used within 24 hours of collection. The pH was 8 and the suspended solids level of the sample was 2.8 g/l. Consequently, no adjustment of these characteristics was considered necessary.
- Test type:
- other: aerobic
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- None
- Hardness:
- Approximately 120 - 180 mg/l as CaCO3
- Test temperature:
- 20 +/- 2°C
- pH:
- 8.0
- Dissolved oxygen:
- 02 consumption rates (mg O2/l/min):
- control: 0.422 - 0.436
- solvent control: 0.386 - 0.400
- test item: 0.400 - 0.407
- reference: 0.067 - 0.319 - Salinity:
- freshwater used
- Nominal and measured concentrations:
- Nominal concentration: 10 mg/l test item
- Details on test conditions:
- At t = 0, 16 ml of synthetic sewage was made up to 300 ml with water in a 1 litre glass beaker. An aliquot, 200 ml, of inoculum was added and the mixture aerated at approximately 0.5 - 1 litre per minute with compressed air via a narrow bore glass tube. Thereafter, at 15-minute intervals, further cultures were prepared following the same procedure but with the addition of appropriate amounts of test or reference substance to the vessels prior to
adjusting the volume and adding the inoculum. The series was completed by a second Control culture. The cultures were then incubated for a maximum of 3 hours at 19°C under normal laboratory lighting. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol (Aldrich Chemical Co Ltd, Batch no. 41205, Purity 97%). The reference substance was dissolved in dilution water with the aid of ultrasonic disruption.
- Key result
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: 95% CL could not be calculated
- Duration:
- 3 h
- Dose descriptor:
- IC0
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- 3,5-dichlorophenol: EC50 (3 hours) = 8 mg/l
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 (respiration inhibition) value for P5367 with activated sewage sludge has been determined as > 10 mg/l for the 3 hour contact time.
- Executive summary:
The study was performed 1996 as GLP-test following OECD-testing method 209 using a mixed population of activated sewage sludge micro- organisms. Due to the low solubility, the test item was dissolved in an auxiliary solvent, 10% Tween 80 dimethylformamide mixture. The test was performed under static conditions with a nominal test item concentration of 10 mg/l, which was the highest test concentration in the test medium at which a stable dispersion could be formed with the solvent. Therefore. it was regarded as impossible to test at higher concentrations of P5367 in the test medium. The IC50 was determined to be above the maximum tested concentration of 10 mg/l.
The EC50 (respiration inhibition) value for P5367 with activated sewage sludge has been determined as > 10 mg/l for the 3 hour contact time.
Reference
The highest test concentration employed in this study, 10 mg/l. was the highest test concentration in the test medium at which a stable dispersion could be formed with the solvent. Therefore. it was regarded as impossible to test at higher concentrations of P5367 in the test medium. The dispersion was stable, visually, for approximately 1 hour.
Description of key information
The study was performed in 1996 as GLP-test following OECD-testing method 209 using a mixed population of activated sewage sludge micro- organisms. Due to the low solubility, the test item was dissolved in an auxiliary solvent, 10% Tween 80 dimethylformamide mixture. The test was performed under static conditions with a nominal test item concentration of 10 mg/l, which was the highest test concentration in the test medium at which a stable dispersion could be formed with the solvent. Therefore. it was regarded as impossible to test at higher concentrations of P5367 in the test medium. The IC50 was determined to be above the maximum tested concentration of 10 mg/L. The EC50 (respiration inhibition) value for P5367 with activated sewage sludge has been determined as > 10 mg/L for the 3-hour contact time.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 10 mg/L
Additional information
Source: GLP-report
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