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Diss Factsheets
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EC number: 203-561-1 | CAS number: 108-21-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Reliable guideline studies of isopropyl acetate are not available. The following reliable information is available for surrogate substances on the algae S subspicatus:
Ethyl acetate: 96hr EC50: >100mg/l, 5600mg/l
isobutyl acetate: 96hr EC50: 370mg/l. NOEC=95mg/l
The QSAR ECOSAR predicts that the toxicity to algae will be intermediate between the EC50 values for these two substances. As a conservative approach, the value for isobutyl acetate is taken as a proxy for the toxicity of isopropyl acetate
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 370 mg/L
- EC10 or NOEC for freshwater algae:
- 95 mg/L
Additional information
No reliable algal toxicity studies have been identified for isopropyl acetate. Bringmann and Kuhn (1978) reported toxicity threshold values for isopropyl acetate in algae. 8 -day EC3 values were 165 mg/L and 1400 mg/L in S. quadricauda and M. aeruginosa, respectively. The extended 8-day exposure in these studies have been criticized as unreliable as exponential growth cannot be assured over such a period of time. Algal toxicity data have been reported for structurally similar alcohol esters of acetic acid. Reliable studies of ethyl acetate and n-butyl acetate generated EC50 values of 5600 mg/L (48 hr) and 370 mg/L (72 hr), respectively.
Reliable studies are available for members of the alkyl acetate family either side of isopropyl acetate in the homologous series. QSAR modelling suggests that the toxicity of isopropyl acetate will be more than ethyl acetate but less than butyl acetate. On this basis, the available data for butyl acetate will be used as a conservative basis to derive the key parameter for this end point.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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