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Diss Factsheets
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EC number: 201-236-9 | CAS number: 79-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP data; methodology predates or was not conducted according to standardized guidelines; no analytical verification of test compound concentrations
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Wistar rats, NDMI mice, and guinea pigs were exposed to aersolised tetrabromobisphenol-A for eight hours, followed by a 48 hour observation period and necropsy.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- - Name of test material (as cited in study report): Tetrabromobisphenol-A
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance):N/A
- Smiles notation (if other than submission substance):N/A
- InChl (if other than submission substance):N/A
- Structural formula attached as image file (if other than submission substance): see Fig.N/A
- Substance type: Monoconstituent
- Physical state: Solid, white powder
- Analytical purity: Not reported
- Impurities (identity and concentrations):Not reported
- Composition of test material, percentage of components:Not reported
- Isomers composition:Not reported
- Purity test date:Not reported
- Lot/batch No.: Not reported; received from Great Lakes Chemical Corp.
- Expiration date of the lot/batch: Not reported
- Radiochemical purity (if radiolabelling): N/A
- Specific activity (if radiolabelling): N/A
- Locations of the label (if radiolabelling): N/A
- Expiration date of radiochemical substance (if radiolabelling): N/A
- Stability under test conditions: Not reported
- Storage condition of test material: Not reported
Constituent 1
Test animals
- Species:
- other: 1) Rat; 2) Mouse; 3) Guinea pig
- Strain:
- other: 1) Wistar; 2) NMDI; 3) Not reported
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported (in-house cultures)
- Age at study initiation: Adult?
- Weight at study initiation: Not reported
- Fasting period before study: Not reported
- Housing: Stainless steel inhalation chambers
- Diet (e.g. ad libitum): Standard laboratory diet, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: One week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22C
- Humidity (%): 50-60%
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported, ambient?
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Stainless steel inhalation chamber
- Exposure chamber volume: Not reported
- Method of holding animals in test chamber: Whole animal placed in chamber
- Source and rate of air: Continuous airflow, flow rate not reported
- Method of conditioning air: Not reported
- System of generating particulates/aerosols: Draeger/Lubeck aerosol apparatus
- Method of particle size determination: Not reported
- Treatment of exhaust air: Not reported
- Temperature, humidity, pressure in air chamber: 22C, 50-50%, Not reported
TEST ATMOSPHERE
- Brief description of analytical method used: No analysis performed
- Samples taken from breathing zone: N/A, no analysis performed
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: No analysis performed
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): No analysis performed - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 24 h
- Concentrations:
- 0.5 mg/l air
- No. of animals per sex per dose:
- Five males and five females per species
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 48 hours
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: Yes - Statistics:
- None reported
Results and discussion
- Preliminary study:
- None
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 0.5 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: rat
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 0.5 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: mouse
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 0.5 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: guinea pig
- Mortality:
- None
- Clinical signs:
- other: None
- Body weight:
- Not measured as an endpoint
- Gross pathology:
- No significant findings or pathologic lesions
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- TBBPA was not acutely toxic by inhalation in rats, mice or guinea pigs.
- Executive summary:
Groups of 10 Wistar rats, 10 NMDI-mice, and 10 guinea pigs (five of each sex/group) were exposed for 8 h to a concentration of 0.5 mg TBBPA/L air, and observed for 48 h after exposure. None of the animals showed symptoms of local or systemic toxicity. No gross pathological findings were observed on necropsy. The 8 h LC50 in three mammalian species was >0.5 mg/L air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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