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Diss Factsheets
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EC number: 200-900-5 | CAS number: 75-77-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Introduction
There are no in vivo data on the toxicokinetics of chlorotrimethylsilane. The following summary has therefore been prepared based on validated predictions of the physicochemical properties of the substance itself and its hydrolysis products.Chlorotrimethylsilane is a moisture-sensitive, volatile liquid. Rapid hydrolysis occurs, producing trimethylsilanol (TMS; CAS 1066-40-6) and hydrogen chloride (HCl). Exposure may occur via the inhalation or dermal routes. Relevant inhalation exposure would be to the hydrolysis products (hydrolysis would occur rapidly when inhaled, even if a mixture of parent and hydrolysis products were present in air). The substance would also hydrolyse rapidly in contact with moist skin. The resulting HCl hydrolysis product would be severely irritating or corrosive.
Absorption
Oral
Significant oral exposure is not expected for this corrosive substance.
Dermal
No measured dermal penetration data are available for the substance itself. However, in a well conducted guideline study conducted to OECD 428 and GLP (reliability score 1), the total percentage of the dose of the hydrolysis product, 14C-TMS, absorbed was estimated to be <0.08% of the applied dose. Almost all (99.9%) of the recovered 14C-TMS volatilised from the skin surface and was captured in the charcoal baskets placed above the exposure sites. The majority of the absorbed dose penetrated through the skin to the receptor fluid. Therefore once hydrolysis has occurred, absorption of trimethylsilanol is poor. Since the other hydrolysis product, HCl is corrosive to the skin, damage to the skin might increase penetration. Deaths, and lung and liver pathology in the key acute dermal study provide evidence that chlorotrimethylsilane is absorbed in vivo following exposure to high doses (in the presence of severe dermal irritation).
Inhalation
The moderate partition coefficient of 1.19 and small molecular weight of the hydrolysis products are favourable for absorption directly across the respiratory tract epithelium by passive diffusion. As with dermal exposure, damage to membranes caused by the corrosive nature of the HCl hydrolysis product might enhance the uptake. Acute inhalation studies showed local signs of corrosion, but no definite systemic effects.
Distribution
All absorbed material is likely to be in the form of the hydrolysis products, trimethylsilanol and hydrogen chloride. Trimethylsilanol is a small molecule, and is likely to be widely distributed. The log Kow of this hydrolysis product means that it is likely to distribute widely into cells, and intracellular concentrations might be higher than the extracellular concentration, particularly in fatty tissues. Hydrogen and chloride ions will enter the body’s natural homeostatic processes.
Metabolism
Chlorotrimethylsilane is rapidly hydrolysed to trimethylsilanol and hydrogen chloride in the presence of moisture. It is likely to occur before absorption into the body. There is no data regarding the metabolism of DMSD. Genetic toxicity tests in vitro showed no observable differences in effects with and without metabolic activation.
Excretion
The molecular weight of TMS suggests that it will be excreted in urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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