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EC number: 219-433-3 | CAS number: 2436-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 13, 1979 to February 27, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study performed similarly to OECD guideline 401 with minor deviations: no data on purity, source, no certificate of analysis of the test substance; no details on environmental conditions (humidity, air changes and photoperiod); 10 instead of 5 animals used; weight variations in animals exceed ± 20% of the mean weight; study performed only in male rats
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no data on purity, source, no certificate of analysis of the test substance; no details on environmental conditions; 10 instead of 5 animals used; weight variations in animals exceed ± 20% of the mean weight; study performed only in male rats
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,7-dimethylocta-1,6-diene
- EC Number:
- 219-433-3
- EC Name:
- 3,7-dimethylocta-1,6-diene
- Cas Number:
- 2436-90-0
- Molecular formula:
- C10H18
- IUPAC Name:
- 3,7-dimethylocta-1,6-diene
- Details on test material:
- - Name of test material (as cited in study report): 79-16229, Dihydromyrcene, 0-67-4945
- Physical state: Clear liquid
- Specific gravity: 0.74
- Sample received: December 27, 1979
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals
- Age at study initiation: Eight weeks
- Weight at study initiation: 176-331 g
- Fasting period before study: 16-20 hours
- Housing: Animals were housed five/cage in suspended wire mesh cages
- Diet: Fresh Purina rat chow; ad libitum
- Water: Ad libitum
- Acclimation period: One week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21 °C
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality, toxicity and pharmacological effects were observed 3-4 hours after dosing and once daily for 14 days
- Necropsy of survivors performed: Yes; surviving animals were killed and examined grossly - Statistics:
- LD50 was calculated according to the method of Litchfield JT and Wilcoxon F, 1949.
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1/10 animal died on Day 7
- Clinical signs:
- other: - Lethargy and piloerection were observed in all animals 3-4 hours after dosing; isolated instances of oily anogenital area, lethargy, chromorhinorrhea, chromodacryorrhea, emaciation and ataxia were noted during the early part of study - All surviving ani
- Gross pathology:
- - Necropsy of animal which died on Day 7 revealed heavily congested and moderately hemorrhagic lungs; moderately dilated heart and a slightly distended stomach containing white fluid mass.
- Necropsy of the surviving animals revealed no abnormalities. - Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 for Dimethyloctadiene is higher than 5000 mg/kg bw in Wistar rats and therefore it is not classified according to the Annex VI of Directive 67/548/EEC and according to the CLP Regulation (EC) n° 1272/2008.
- Executive summary:
In an acute oral toxicity study (limit test) performed similarly to OECD guideline 401, a group of 10 male Wistar rats were given a single oral dose by gavage of Dimethyloctadiene (in the report the synonym Dihydromyrcene was used) at 5000 mg/kg bw. Animals were then observed for mortality and clinical signs of toxicity for 14 days and were all macroscopically necropsied after death or sacrifice.
Only 1/10 animal died on Day 7. Major signs of toxicity noted after 3-4 hours of dosing in all animals were lethargy and piloerection. Isolated instances of oily anogenital area, lethargy, chromorhinorrhea, chromodacryorrhea, emaciation and ataxia were also noted during the early part of study. All surviving animals were normal from Day 7 to 14 except an instance of diarrhea on Day 12. Necropsy of the animal which died on Day 7 revealed heavily congested and moderately hemorrhagic lungs, moderately dilated heart and a slightly distended stomach containing white fluid mass. Necropsy of the surviving animals revealed no abnormalities.
The oral LD50 for Dimethyloctadiene is higher than 5000 mg/kg bw in Wistar rats and therefore it is not classified according to the Annex VI of Directive 67/548/EEC and according to the CLP Regulation (EC) n° 1272/2008.
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