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EC number: 614-114-9 | CAS number: 67746-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 March 2010 - 12 March 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and/or EC guidelines and according to GLP principles
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: TOC-analysis from the WAF prepared at a loading rate of 100 mg/l and the untreated control
- Sampling method:
Frequency at t=0 h and t=48 h
Volume 40 ml
Storage Samples were stored in a refrigerator until analysis - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
Preparation of the test solutions started with loading rates prepared individually at 1.0, 10 and 100 mg/l applying 48 hours of magnetic stirring to achieve maximum dissolution in test medium. The magnetic stirring was followed by a settlement period of 2 hours. This resulted in clear and colourless solutions with a floating layer. The Water Accommodated Fractions (WAFs) were then collected by siphoning the water phase. The final test solutions were all clear and colourless - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
-Common name: Daphnia magna
- Source: In-house laboratory culture
- Age at study initiation: < 24 hours
-Method of breeding: With newborn daphnids, i.e. less than 3 days old, by placing about 250 of them into 5 litres of medium in an all-glass culture vessel
- Feeding during test: No - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- The hardness: 180 mg/l expressed as CaCO3
- Test temperature:
- between 19.2 and 20.3°C
- pH:
- At t=0 h: 7.7-7.8
At t=48 h:7.9 - Dissolved oxygen:
- At t=0 h: 8.9-9.6
At t=48 h:8.9-9.0 - Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal concentrations: WAFs prepared at loading rates of 1.0, 10 and 100 mg/l
Measured concentration: During the test samples for TOC-analysis were taken from the WAF prepared at a loading rate of 100 mg/l and the untreated control. The TOC concentrations measured in the treated samples were only slightly exceeding those measured in the control samples, indicating that the actual test substance concentration was very low. The actual measured concentration was at approximately 0.6 mg C/l when corrected for the carbon measured in the control samples. The TOC content of Standolized linseed oil was determined to be 77.88% . Thus, the actual Standolized linseed oil concentration in solution was approximately 0.8 mg/l. - Details on test conditions:
- Test vessel: 100 ml, all glass
- Type (delete if not applicable): open - ~80 ml,
- Material, size, headspace, fill volume: glass, 100 ml, normal headspace
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4 for the highest concentration, 2 in the lower test concentrations
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Adjusted ISO medium
- Culture medium different from test medium: yes, for culturing M7 medium is used
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours photoperiod daily
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : EC50 daily
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
- Test concentrations: WAFs prepared at loading rates of 1.0, 10 and 100 mg/l - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (K2Cr2O7)
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: > WAF prepared at 100 mg/l
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: > WAF prepared at 100 mg/l
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: WAF prepared at 100 mg/l
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.8 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: TOC
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.8 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: TOC
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.8 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: TOC
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no
- Mortality of control: no
- Other adverse effects control: no - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Mortality: no mortility observed in control
- EC50/LC50:
The 24h-EC50 was 0.75 mg/l with a 95% confidence interval between 0.56 and 1.0 mg/l.
The 48h-EC50 was 0.36 mg/l with a 95% confidence interval between 0.28 and 0.49 mg/l. - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study Standolized linseed oil did not induce acute immobilisation of Daphnia magna when exposed to a WAF prepared at a loading rate of 100 mg/l after 48 hours of exposure (NOEC).
The 48h-EC50 exceeded a WAF prepared at a loading rate of 100 mg/l, which can be considered to represent the maximum soluble concentration in test medium. TOC-analyses showed that the actual concentration in solution approximated 0.8 mg/l.
Reference
Description of key information
48-hour NOEL and EL50: > 100 mg/l
Key value for chemical safety assessment
Additional information
In the key study conducted under GLP and according to OECD 202, Standolized linseed oil did not induce acute immobilisation of Daphnia magna when exposed to a WAF prepared at a loading rate of 100 mg/l after 48 hours of exposure (NOEC).
The 48h-EC50 exceeded a WAF prepared at a loading rate of 100 mg/l, which can be considered to represent the maximum soluble concentration in test medium.
A study on the acute toxicity to Daphnia magna (according to OECD 202, not under GLP) was also conducted with the biodegradation products of Linseed oil, polymerized. Based on the results of this test, it was concluded that the 48h-EC50 of the (total mass of the) biodegradation products is above 1 mg/L. Based on this result it can be concluded that the biodegradation products of Linseed oil, polymerized do not meet the "T" criterion in the PBT assessment.
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