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EC number: 209-810-0 | CAS number: 593-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard method with acceptable restrictions (e.g. non-GLP, no analytical verification of test concentrations)
- Qualifier:
- according to guideline
- Guideline:
- other: German Industrial Standard DIN 38412, Part 15
- GLP compliance:
- no
- Analytical monitoring:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The substance was added to the test water without any pretreatment. Subsequently the fish were placed into the aquaria. - Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- TEST ORGANISM
- Common name: golden orfe
- Source: Fischzucht Paul Eggers, Hohenwestedt, Germany
- Length at study initiation (length definition, mean, range and SD): body length: mean: 7.1 cm; range: 6.2-8.3 cm
- Weight at study initiation (mean and range, SD): mean: 4.6 g; range: 3.4-7.7 g
- Corpulence factor of batch: 1.3
- Feeding during test: no
ACCLIMATION
- Acclimation period: 7 weeks
- Acclimation conditions (same as test or not): not specified
- Type and amount of food: SSNIFF - growing feed F/B-50, ad libitum
- Health during acclimation (any mortality observed): 0 %
ADAPTATION
- Adaptation to test water and test temperature: 3 d - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 2.5 mmol/L
- Test temperature:
- 23+-1 °C
- pH:
- about 7.9
- Nominal and measured concentrations:
- nominal test concentration: 500 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: all-glass aquaria, 30 cm x 22 cm x 24 cm, 10 L
- Aeration: slight
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 4.6 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted freshwater
- guideline: German Industrial Standard DIN 38412, part 11, draft Sept. 1981
- preparation from fully demineralised tap water
- conductivity: max 10 µS
- resalting by addition of
- 294.0 mg/L CaCl2 * 2 H2O
- 123.3 mg/L MgSO4 * 7 H2O
- 64.8 mg/L NaHCO3
- 5.8 mg/L KCl
- continuous aeration with oil-free air
- Test water ready for use:
- Ca/Mg ratio: 4:1
- Na/K ratio: 10:1
- total hardness: 2.5 mmol/L
- acid capacity: 0.8 mmol/L
- pH about 7.9
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light, 8 h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Mortality and symptoms: after 1, 4, 24, 48, 72 and 96 h
- pH, dissolved oxygen and temperature: after 1, 24, 48, 72 and 96 h
TEST CONCENTRATIONS
- Test concentration: 0 (control) and 500 mg/L
- Range finding study
- Results used to determine the conditions for the definitive study: LC50(96 h): > 500 mg/L - Reference substance (positive control):
- yes
- Remarks:
- chloroacetamide
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality: no mortality observed
- Behavioural abnormalities: no symptoms detectable
- Mortality of control: 0 % - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- LC50(48 h): about 32 mg/L - Reported statistics and error estimates:
- Reported LC50 with 1 % significance
- Sublethal observations / clinical signs:
Table 1 - pH: Nominal concentration (mg/L) beginning 24 h 48 h 72 h 96 h 0 (control) 7.7 7.8 7.9 8.0 8.0 500 7.7 7.6 7.8 7.8 7.9 - Dissolved oxygen (mg/L):
Nominal concentration (mg/L) beginning 24 h 48 h 72 h 96 h 0 (control) 7.3 6.7 7.2 7.1 7.2 500 7.4 7.4 7.5 7.0 6.9 - Temperature (°C):
Nominal concentration (mg/L) beginning 24 h 48 h 72 h 96 h 0 (control) 22 24 23 24 23 500 23 24 23 24 24 - Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 > 500 mg/L
- Executive summary:
Trimethylamine hydrochloride, sol. 70 % (CAS 593 -81 -7) was tested in the golden orfe (Leuciscus idus) to evaluate its short-term toxicity potential to fish (BASF, 1987). The test procedure was conducted in accordance with national standard method (DIN 38412, Part 15) with acceptable restrictions (e.g. non-GLP, no analytical verification of test concentrations). The test substance (nominal 500 mg/L) was added to the test water without any pretreatment. Subsequently the fish (10 organisms per vessel) were placed into the aquaria. Mortality and symptoms were evaluated after 1, 4, 24, 48, 72 and 96 h. PH, dissolved oxygen and temperature were measured after 1, 24, 48, 72 and 96 h.
No mortality was observed and no behavioural abnormalities/ symptoms were detected. The LC50 value was determined to be > 500 mg/L.
Reference
Description of key information
Trimethylamine hydrochloride, sol. 70 % (CAS 593 -81 -7) was tested in the golden orfe (Leuciscus idus) to evaluate its short-term toxicity potential to fish (Key study 1, 1987). The test procedure was conducted in accordance with national standard method (DIN 38412, Part 15) with acceptable restrictions (e.g. non-GLP, no analytical verification of test concentrations). The test substance (nominal 500 mg/L) was added to the test water without any pretreatment. Subsequently the fish (10 organisms per vessel) were placed into the aquaria. Mortality and symptoms were evaluated after 1, 4, 24, 48, 72 and 96 h. PH, dissolved oxygen and temperature were measured after 1, 24, 48, 72 and 96 h.
No mortality was observed and no behavioural abnormalities/ symptoms were detected. The LC50 value was determined to be > 500 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 500 mg/L
Additional information
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