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EC number: 205-550-7 | CAS number: 142-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 Oct - 13 Nov 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- limited data; occlusive dressing
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexanoic acid
- EC Number:
- 205-550-7
- EC Name:
- Hexanoic acid
- Cas Number:
- 142-62-1
- Molecular formula:
- C6H12O2
- IUPAC Name:
- hexanoic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean weight 3294 g
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 21 days
Reading time points: immediately, 1, 24, 48 and 72 h and 6, 8, 10, 13, 15, 17 and 21 days after patch removal - Number of animals:
- 5
- Details on study design:
- TEST SITE
- Area of exposure: dorsal area (3 cm x 3 cm)
The substance was applied on shaved skin and covered with a linen lobule.
- Type of wrap if used: polyethylene foil wrapped with an elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing: The skin was cleaned of residual test substance.
- Time after start of exposure: 4 h
SCORING SYSTEM: Draize scoring system
Body weights of the rabbits were determined 7, 14 and 21 days after initiation of the study.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: necrosis and scar tissue
- Basis:
- other: all 5 animals
- Time point:
- other: 21 days
- Reversibility:
- not reversible
- Remarks on result:
- other: scar tissue was observed at the treated sites in all animals at the end of the observation period, indicating irreversible skin damage
- Irritation parameter:
- erythema score
- Time point:
- 24/48/72 h
- Remarks on result:
- other: scores were not given
- Irritation parameter:
- edema score
- Time point:
- 24/48/72 h
- Remarks on result:
- other: scores were not given
- Irritant / corrosive response data:
- Immediately after removal of the dressing, intensive erythema and edema was observed. The edema had disappeared after seven days, the erythema however persisted and passed into a full thickness necrosis.
10 days after initiation of the study eschar started to separate from treated skin. Another 7 days later eschar was completely separated from skin. 21 days after treatment a red scar tissue with single eschar rest had developed. Around the scar tissue, an intensified growth of hair appeared and on the treated skin area, there were just single flocci.
Based on the findings the test material is considered corrosive under the experimental conditions chosen. Corrosive effects are expected even if the study would had been conducted under semiocclusive conditions: As the test material has a very low vapour pressure, evaporating of the test material from the skin through the semiocclusive dressing is rather unlikely. - Other effects:
- The body weights of the animals showed normal growth and were upto 3644 g at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: classification as Skin Corr. 1C, H314 required according to Regulation (EC) No 1272/2008
- Conclusions:
- CLP: Skin Corr. 1C, H314
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