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EC number: 202-267-0 | CAS number: 93-68-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The key study was conducted in year 2008 and reported in year 2009 according to the OECD Guideline for the testing of chemicals 301 F and
principles of GLP.
The first test item replicate reached the 10% level (beginning of biodegradation) after 3 days and the pass level of 60% after 10 days. The biodegradation came to a maximum of 97% on day 23. The second test item replicate reached the 10% level after 4 days and the pass level of 60% after 8 days. The biodegradation came to a maximum of 93% on day 24. The mean biodegradation rate after 28 days was 92%.
Therefore, the test item must be regarded as readily biodegradable in the 10-d-window and after 28 days.
Testing of 2‘-methylacetoacetanilide for inherent biodegradability was performed in the Zahn-Wellens test in the year 1989. The supporting study report was newly generated from archieved laboratory manuscripts. The results of testing the biodegradability in the Zahn-Wellens test revealed that: 2‘-Methylacetoacetanilide is inherently, completely and rapidly biodegradable. The results of this test are only valid tor the tested batch.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
In the key study the first test item replicate reached the 10% level (beginning of biodegradation) after 3 days and the pass level of 60% after 10 days. The biodegradation came to a maximum of 97% on day 23. The second test item replicate reached the 10% level after 4 days and the pass level of 60% after 8 days. The biodegradation came to a maximum of 93% on day 24. The mean biodegradation rate after 28 days was 92%.
The validity criteria of the guideline are fulfilled.
Therefore, the test item is readily biodegradable in the 10 -d-window and after 28 day
In the supporting study an inherent biodegradability test (Zahn-Wellens) was performed in the year 1989.
The report was newly generated from archieved laboratory manuscripts. The criteria for the evaluation as inherently biodegradable according to the definitions for inherent biodegradability in the OECD Guidelines for Testing of Chemicals were mentioned in the chapter ‘Principles of the test procedure. The results of testing the biodegradability in the Zahn-Wellens test revealed that: 2‘-Methylacetoacetanilide is inherently, completely and rapidly biodegradable. The results of this test are only valid tor the tested batch.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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