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Diss Factsheets
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EC number: 211-659-0 | CAS number: 682-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study conducted to OECD 423 and to GLP (LPT, 2002a) the oral LD50 value for tetrapropyl orthosilicate in CD rats was established to exceed 2000 mg/kg bw. There were no clinical signs of toxicity, affects on body weights or macroscopic findings.
There are no acute inhalation data on tetrapropyl orthosilicate therefore good quality data have been read-across from the structurally-related tetraethyl orthosilicate.
The LC50 value of 10.0 mg/l tetraethyl orthosilicate (aerosol) in male rats and >16.8 mg/l in female rats was determined in a reliable study (Hoechst AG, 1991) conducted according to an appropriate test protocol, and in compliance with GLP.
There are no acute dermal data.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 10 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is one reliable acute oral study on tetrapropyl orthosilicate. There are no acute inhalation data on tetrapropyl orthosilicate therefore good quality data have been read-across from the structurally-related tetraethyl orthosilicate (CAS 78-10-4).
In the absence of measured data for tetrapropyl orthosilicate, it is considered appropriate to use this result in support of the acute inhalation toxicity endpoint. The registered substance and read-across substance are both moderately lipophilic substances (log Kow 3.4 and 3.0, respectively) for which uptake across the respiratory tract is favourable. The vapour pressures of the substance (0.26 Pa (predicted) and 110 Pa (measured)) indicate that exposure by the inhalation route is potentially more significant for the read-across substance and, since the study used an aerosol, it can be considered as a worst-case in respect of likely exposure.
After uptake both substances hydrolyse rapidly with half-lives of 1.6 and 2.5 hours respectively at pH 7 and 37.5°C forming propanol or ethanol and silicic acid. Neither propanol nor ethanol is acute harmful by the inhalation route, with reported LC50 values of:
42 mg/l for n-propanol (Union Carbide Corp. 1992, cited in ESR Risk Assessment Report for Propan-1 -ol, EC, 2008).
>114 mg/l for ethanol (1-hour, mouse, cited in SIAR, OECD, 2004).
Since the two substances share the common hydrolysis product, silicic acid, and no enhanced toxity would thus be expected from hydrolysis to propanol rather than ethanol at test concentrations relevant to current guideline limit values, it is considered appropriate to read-across the available inhalation result. Read-across is discussed in more detail in Section 7.5.
Justification for selection of acute toxicity – oral endpoint
The selected study is the only acute oral toxicity study available for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for selection of acute toxicity – inhalation endpoint
The selected study is the only acute inhalation toxicity study available for an appropriate surrogate substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for classification or non-classification
The oral LD50 is greater than 2000 mg/kg bw/day, and the inhalation LC50 (aerosol) is 10 mg/l (based on read-across). There are therefore no data to suggest that tetrapropyl orthosilicate should be classified on the basis of its lethality according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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