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Diss Factsheets
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EC number: 237-898-0 | CAS number: 14059-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Bioaccumulation
C.I. Pigment Yellow 184 does not significantly accumulate in organisms as expected regarding the extremely low water solubility. The bioconcentration factors determind in a study on Oryzias latipes ranged from < 1.2 to < 14.
This is supported by data on vanadium. In a review by Miramand & Fowler (1998) data from areas of likely local contamination from industrial sources are reported. The authors calculated concentration factors for components of a typical marine food chain based on average seawater concentrations of 2 ng/g and reported levels of vanadium in marine organisms.
Concentration factors for primary producers ranged from 40 to 560, for primary consumers from 40 to 150, for secondary consumers from approximately 20 to 150, and for tertiary con sumers from approximately 2 to 400.
With the exception of ascidians (tunicates), some annelids, and molluscs, concentrations of vanadium in marine organisms are low
Organisms generally do not concentrate or accumulate vanadium from environmental media to a high degree, and there is no indication of biomagnification in food chains.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Absorption
The bioavailability of the test material is low following oral, inhalation and intraperitoneal exposure as evidenced by no observed toxicity in the acute oral study up to 5000 mg/kg bw, no systemic effects in subacute and subchronic repeated dose studies and an in vivo micronucleus test after intraperitoneal administration.
Additionally, bioavailability of the vanadium ion was not observed in any of the repeated dose inhalation studies as all measurements in the different tissue types were either below or at the limit of detection. The low bioavailability of the bismuth vanadate is in agreement with the dissolution of bismuth vanadate in comparison with vanadium pentoxide which was done according to the OECD 29 protocol (see water solubility). The test revealed that the concentration of bismuth and vanadium were at or below the limit of detection at pH 5.5 and 6.5 and only slightly above the limit of detection at pH 8.5.
Distribution
In a 28 -day repeated dose study the test substance did not translocate to the liver or the brain after inhalation exposure and low amounts of bismuth were found in the kidney only at the highest dose tested. Vanadium was also detected in the kidney at the highest dose, albeit only around the limit of detection. This is in line with the low solubility (< 1.0 µg/L at 20 °C) of the test substance at physiological pH values (5.5 - 8.0) as determined by a study following the OECD 29 protocol (see water solubility).
Excretion
Information on the excretion is not available, although information gained from the acute oral study indicate that little if any of the substance is taken up from the gastro intestinal tract and therefore excreted unchanged via the feces. Feces appeared greenish / yellowish one day after oral administration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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