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EC number: 249-951-5 | CAS number: 29911-28-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March-July 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD guideline 402
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(2-butoxy-1-methylethoxy)propan-2-ol
- EC Number:
- 249-951-5
- EC Name:
- 1-(2-butoxy-1-methylethoxy)propan-2-ol
- Cas Number:
- 29911-28-2
- Molecular formula:
- C10H22O3
- IUPAC Name:
- 1-(2-butoxy-1-methylethoxy)propan-2-ol
- Details on test material:
- Identity: Dowanol-DPnB (n-butoxypropoxypropanol or
dipropylene glycol normal-butyl ether).
CAS # 29911-28-2
Batch No.: XZ 95411.00
Purity: More than 95%
Appearance: Clear liquid.
Administered as: Undiluted liquid.
Vapor pressure: Not reported.
Specific Gravity: 0.91 g/ml.
Solubility: 5% in water.
Stability: Stable up to 200°C.
Dipropylene glycol n-butyl ether (DPnB) is a mixture of 4
possible isomers with the major isomers being
1-(1-n-butoxy-2-propoxy)-2-propanol and
2-(1-n-butoxy-2-propoxy)-1-propanol.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River GmbH
- Age at study initiation: about 8 weeks
- Weight at study initiation: Males: 308-356 g, Females: 211-225 g
- Fasting period before study: none
- Housing: individually housed 7 days prior to testing
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21
- Humidity (%): 30-70
- Air changes (per hr): n/a
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: n/a
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- A group of 5 male and 5 female Wistar rats (~7 weeks old) was treated with a single dose of 2,000 mg/kg dipropylene glycol n-butyl ether applied topically to the intact skin under occlusion for a period of 24 hours.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Subjects were observed for clinical signs of toxicity and mortality during the application period and for a period of 14 days after removal of the test material. The skin of the rats at the site of application was also evaluated for signs of irritation over the course of the study. The pure test material was applied at a single dose of 2,000 mg/kg to approximately 10% of the total body surface area of skin (clipped, non-abraded) of the rats. The test material was applied to gauze patches, which were then affixed to the clipped area of the skin and covered with foil and wrapped with a bandage around the torso. The test material was held in contact with the skin for a period of 24 hours whereupon it was removed and the treated area was washed with water to remove remaining test material. On the day of treatment (day 0), animals were observed frequently for toxicity and morbidity. Thereafter, subjects were checked once daily except for weekends and holidays. Individual body weights were recorded on test days 0, 7, and 14. The treated areas of skin were examined on test days 4, 7, and 14 for signs of irritation. Animals were sacrificed on day 14 and subjected to gross necropsy.
- Statistics:
- none
Results and discussion
- Preliminary study:
- n/a
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occurred over the course of the study.
- Clinical signs:
- other: No clinical signs of toxicity or skin irritation occurred over the course of the study.
- Gross pathology:
- No test material related gross abnormalties were identified.
- Other findings:
- none
Any other information on results incl. tables
The dermal LD50 for dipropylene glycol n-butyl ether is greater than 2,000 mg/kg for male and female Wistar rats.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not classified for acute dermal toxicity according to EU criteria as the LD50 is greater than 2 000 mg/kg bw.
- Executive summary:
A group of 5 male and 5 female Wistar rats (~7 weeks old) was treated with a single dose of 2,000 mg/kg dipropylene glycol n-butyl ether applied topically to the intact skin under occlusion for a period of 24 hours. Subjects were observed for clinical signs of toxicity and mortality during the application period and for a period of 14 days after removal of the test material. The skin of the rats at the site of application was also evaluated for signs of irritation over the course of the study. The pure test material was applied at a single dose of 2,000 mg/kg to approximately 10% of the total body surface area of skin (clipped, non-abraded) of the rats. The test material was applied to gauze patches, which were then affixed to the clipped area of the skin and covered with foil and wrapped
with a bandage around the torso. The test material was held in contact with the skin for a period of 24 hours whereupon
it was removed and the treated area was washed with water to remove remaining test material. On the day of treatment
(day 0), animals were observed frequently for toxicity and morbidity. Thereafter, subjects were checked once daily
except for weekends and holidays. Individual body weights were recorded on test days 0, 7, and 14. The treated areas
of skin were examined on test days 4, 7, and 14 for signs of irritation. Animals were sacrificed on day 14 and subjected
to gross necropsy.No deaths, clinical signs of toxicity, or skin irritation occurred over the course of the study. The dermal LD50 for dipropylene glycol n-butyl ether is greater than 2,000 mg/kg for male and female Wistar rats.
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