Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only short description.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID DATA SHEET(108-31-6)
- Author:
- European Commission-European Chemicals Burean
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Maleic anhydride
- EC Number:
- 203-571-6
- EC Name:
- Maleic anhydride
- Cas Number:
- 108-31-6
- Molecular formula:
- C4H2O3
- IUPAC Name:
- furan-2,5-dione
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Small Russian White rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Duration of treatment / exposure:
- 5 minutes
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
- Other effects:
- No other effect showed in this study
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to this study maleic anhydride is considered to be corrosive to eyes in rabbits.
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